Gene ML2185
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | CATALYZES THE PRINCIPAL CONVERSION OF SATURATED FATTY ACIDS TO UNSATURATED FATTY ACIDS. THOUGHT TO CONVERT STEAROYL-ACP TO OLEOYL-ACP BY INTRODUCTION OF A CIS DOUBLE BOND BETWEEN CARBONS DELTA-9 AND DELTA-10 OF THE ACYL CHAIN [CATALYTIC ACTIVITY: Stearoyl-[acyl-carrier protein] + AH2 + O2 = oleoyl-[acyl-carrier protein] + A + 2 H2O]. |
| Product | PROBABLE ACYL-[ACYL-CARRIER PROTEIN] DESATURASE DESA1 (ACYL-[ACP] DESATURASE) (STEAROYL-ACP DESATURASE) (PROTEIN DES) |
| Comments | ML2185, len: 338 aa. Probable desA1 acyl-[acyl-carrier protein] desaturase (stearoyl-ACP desaturase) (EC 1.14.99.6). Similar to Mycobacterium tuberculosis protein desA1 Rv0824c TR:Q50824 (EMBL:U49839) fasta scores: E(): 0, 79.9% in 338 aa, and to Oryza sativa acyl-[acyl-carrier protein] desaturase precursor SW:STAD_ORYSA (Q40731) fasta scores: E(): 2e-19, 28.3% in 300 aa. Also similar to ML1952 from M. leprae. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2599223 | 2600239 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2185|desA1
MSAELTDLQLLHELEPVVEKYMNRHERLHKNWNPHDYIPWSDGKNFYALGGQDWDPEQSQLSDVAQVAMVQNLVTEDNLPSYHREIAMTMGMDGAWGQWVNRWTAEENRHGIALRDYLVVTRAVDPVELEKLRIEVVNRGFSPGQNHQGGLFADTLFDSILYVTFQELATRVSHRNTGKACNETIADQLLAKISSDENLHMIFYRDVSEAGIELAPNLAIKALHKILHNFKMPGFLVPEFRRKAVIIAVGGVYDIRIHLDEVVMPVLKKWRILEREDFSGEGTRLRDEIGEHLTELEAACDKFEVSKQRYIEREARRTEKITARKVLSTEGTLRMSGR
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