Gene ML2205c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepurM
Gene length1095 bp
IdentifierML2205c
Location 2619428 bp
Protein summary information
Molecular mass38352.0 Da
Isoelectric point5.11
Protein length365 amino acids
Structural information
PFAMPF00586, PF02769
Orthologs
M. tuberculosis H37RvRv0809
M. lepromatosis Mx1-22AMLPM_2205
Cross-references
UniProtQ9CBC2
Gene OntologyCytoplasm, Phosphoribosylformylglycinamidine cyclo-ligase activity, 'de novo' imp biosynthetic process
Enzyme Classification6.3.3.1
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE)
CommentsML2205c, len: 364 aa. Probable purM, 5'-phosphoribosyl-5-aminoimidazole synthetase (EC 6.3.3.1). Similar to Mycobacterium tuberculosis 5'-phosphoribosyl-5-aminoimidazole synthetase Rv0809 TR:O53823 (EMBL:AL022004) fasta scores: E(): 0, 87.1% identity in 364 aa, and to Bacillus subtilis phosphoribosylformylglycinamidine cyclo-ligase PURM SW:PUR5_BACSU (P12043) fasta scores: E(): 0, 46.4% identity in 334 aa. Contains Pfam match to entry PF00586 AIRS, AIR synthase related protein.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS26194282620522-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2205c|purM
MMDPGKSPGGQLGNHGITYASTGVDIEAGDRSVELFKPMAVKAIRTEVLGGLGGFAGLFALRSGYREPVLAASTDGVGTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGRTVPERLSAIVDGIAEGCMLAGCALLGGETAEHPGLMEVDHYDIAATGVGVVEADDTLGPDRVKPGDVIIALRSSGLHSNGYSLARSVLLEIDRMNLAGYVEEFGRTLGEELLEPTRIYAKDCLALAAETHVRTFCHVTGGGLAGNLQRVIPHGLVAEVDRGTWTPAPVFAMIAQRGRVAREEMEKTFNMGVGMIAVVAPEDTDRALAILTARHLDCWVLGTVCKGSKVGPRAKLVGQHPRF
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