Gene ML2206c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepurF
Gene length1671 bp
IdentifierML2206c
Location 2620622 bp
Protein summary information
Molecular mass59507.9 Da
Isoelectric point6.59
Protein length557 amino acids
Structural information
PFAMPF00156, PF00310
Orthologs
M. tuberculosis H37RvRv0808
M. lepromatosis Mx1-22AMLPM_2206
Cross-references
UniProtQ50028
Gene OntologyAmidophosphoribosyltransferase activity, Glutamine metabolic process, Iron ion binding, Magnesium ion binding, Nucleoside metabolic process, Purine nucleobase biosynthetic process, Purine nucleotide biosynthetic process, 4 iron, 4 sulfur cluster binding
Enzyme Classification2.4.2.14
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductAMIDOPHOSPHORIBOSYLTRANSFERASE PURF (GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE) (ATASE) (GPATASE)
CommentsML2206c, len: 556 aa. Probable purF, amidophosphoribosyltransferase (EC 2.4.2.14). Similar to Mycobacterium tuberculosis amidophosphoribosyltransferase precursor Rv0808 SW:PUR1_MYCTU (O06626) fasta scores: E(): 0, 91.3% identity in 518 aa, and to Bacillus subtilis amidophosphoribosyltransferase precursor PURF SW:PUR1_BACSU (P00497) fasta scores: E(): 0, 45.1% identity in 470 aa. Contains 2 Pfam matches to entry PF00310 GATase_2, Glutamine amidotransferases class-II. Contains Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain. Contains PS00103 Purine/pyrimidine phosphoribosyl transferases signature.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS26206222622292-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2206c|purF
VCLAVGVGVRAPKHVPQIRRLGRAGRRLRCVTNCALGSCPIVTVQQPGRDFSSPREECGVFGVWAPGELVAKLTYFGLYALQHRGQEAAGIAVADGSQVLVFKDLGLVSQVFDEQTLAAMEGHVAIGHCRYSTTGDTTWENAQPVFRNIAAGSGVALGHNGNLVNTAELAARARDAGLIAKRCPAPATTDSDILGALLAHGAADSTLEQAALELLPTVRGAFCLTFMDENTLYACRDPYGVRPLSLGRLDRGWVVASETAGLDIVGASFVRDIEPGELLAIDADGVRSTRFANPTPKGCVFEYVYLARPDSTLAGRSVHGTRVEIGRRLARECPVEADLVIGVPESGTPAAVGYAQESGISYGQGLMKNAYVGRTFIQPSQTIRQLGIRLKLNPLKEVIRGKRLIVVDDSVVRGNTQRALVRMLREAGAVELHVRIASPPVKWPCFYGIDFPSPAELIANVVADEEEMLEAVRQGIGADTLGYISLRGMIAASEQPASRLCYACFDGRYPIELPSEAMLGKNVIEHMLANAARGAGLRDLAADQVPVDADENCVWR
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