Gene ML2211c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepurL
Gene length2265 bp
IdentifierML2211c
Location 2626960 bp
Protein summary information
Molecular mass80098.6 Da
Isoelectric point4.46
Protein length755 amino acids
Structural information
PFAMPF00586, PF02769
Orthologs
M. tuberculosis H37RvRv0803
M. lepromatosis Mx1-22AMLPM_2211
Cross-references
UniProtQ50023
Gene OntologyAtp binding, Cytoplasm, Phosphoribosylformylglycinamidine synthase activity, 'de novo' imp biosynthetic process
Enzyme Classification6.3.5.3
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II PURL (FGAM SYNTHASE II)
CommentsML2211c, len: 754 aa. purL, phosphoribosylformylglycinamidine synthase II (EC 6.3.5.3). Similar to Mycobacterium tuberculosis phosphoribosylformylglycinamidine synthase II PURL OR Rv0803 OR MTCY07H7A.06C SW:PURL_MYCTU (P54876; O06631) fasta scores: E(): 0, 90.3% identity in 754 aa, and to Bacillus subtilis phosphoribosylformylglycinamidine synthase ii PURL SW:PURL_BACSU (P12042) fasta scores: E(): 0, 43.0% identity in 739 aa. Contains 2 Pfam matches to entry PF00586 AIRS, AIR synthase related protein.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS26269602629224-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2211c|purL
VIDTVEYAATTPDQPQPFAELGLREDEYQRVREILGRRPTDTELAMYSVMWSEHCSYKSSKVHLRYFGETTTEEMRTGMLAGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATGVGGIVRDIMAMGARPVAVMDQLRFGAADALDTRRVLDGVVRGIGGYGNSLGLPNIGGETVFDSCYDGNPLVNALCVGVLRQEDLHLAFASGAGNKIILFGACTGLDGIGGVSVLASDTFDAEGARKKLPSVQVGDPFMEKVLIECCLELYAGGLVIGIQDLGGAGLSCATSELASAGDVGMAIQLDTVPRRAKDMTPAEVFCSESQERMCAVVAPENVDAFLAVCRKWEVLATVIGEVTDGDRLRITWHGETVVDVPPRTVAHEGPVYQRPVSRPESQEALNADSSKGLPRPVSGDELRATLLALLGSPHLCSRAFITEQYDRYVRGNTVLAEHADAGVLRIDESTGRGIALSTDASGRYTRLDPYAGAQLALAEAYRNVAVTGATPVAVTNCLNFGSPEDPGVMWQFAQAVRGLADGCAALKIPVTGGNVSFYNQTGAVAILPTPVVGVLGVLDNVARRIHTSLGTEPGEILMLLGDTYDEFDGSVWAQVMAGHLGGLPPMVDLAREKLLAEVLSSASRDELVSAAHDLSEGGLAQAIVESALAGETGCRIALPEDADPFVMLFSESAGRVLVAVPRPEESRFRSMCEARGLPAMRIGVVDQGSDSIEVRGQFTVSLAELRMTFEAVLPRFFG
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