Gene ML2230c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN DE NOVO PURINE BIOSYNTHESIS (AT THE EIGHT STEP) [CATALYTIC ACTIVITY: 1-(5-PHOSPHORIBOSYL)-4-(N-SUCCINO-CARBOXAMIDE) -5-AMINOIMIDAZOLE = FUMARATE + 5'-PHOSPHORIBOSYL-5-AMINO-4-IMIDAZOLECARBOXAMIDE (ALSO CATALYZES: N6-(1,2-DICARBOXYETHYL)AMP = FUMARATE + AMP)]. |
| Product | PROBABLE ADENYLOSUCCINATE LYASE PURB (ADENYLOSUCCINASE) (ASL) (ASASE) |
| Comments | ML2230c, len: 472 aa. Probable purB, adenylosuccinate lyase (EC 4.3.2.2). Similar to Mycobacterium tuberculosis hypothetical 51.0 kda protein cy369.21b Rv0777 OR MTCY369.21B TR:P71832 (EMBL:Z80226) fasta scores: E(): 0, 86.4% identity in 472 aa, and to Saccharomyces cerevisiae adenylosuccinate lyase ADE13 OR YLR359W OR L8039.12 SW:PUR8_YEAST (Q05911) fasta scores: E(): 0, 34.5% identity in 449 aa. Contains Pfam match to entry PF00206 lyase_1, Lyase. Contains PS00163 Fumarate lyases signature. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2647530 | 2648948 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2230c|purB
VSIPNVLAARYASAELVAIWSPEARVIAERQLWLAVLRAQAELSVPMPVKAIADYERVLGEVDLASIAARERVLRHDVKARIEEFNALAGHEQVHKGMTSRDLTENVEQLQIRRSLELVFCHGVAVVARLAECAVSYRDLVMAGRSHNVAAQATTLGKRFASATQETLIALTRLRELIDRYPLRGIKGPMGTGQDMLDLLGGDAAALAELEQRIAEFLGFTKVLASVGQVYPRSLDHDVISALVQLGAGSSSLAHTIRLMAGHELVTEGFAPGQVGSSAMPHKMNSRSCERVNGLQVVLRGYAAMAAELAGAQWNEGDVFCSVVRRVALPDSFFAIDGQIETFLTVLDEFGAYPAVIRRELDRYLPFLATTKVLIAAVRAGMGREAAHHVIREHAVATALAMRECGAEPDLLDRLAADGRLPLDRAALDAALADKKAFTGAAADQVDEVVAMVDKLVGRYPEAAKYTPGAIL
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