Gene ML2254 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameotsA
Gene length1497 bp
IdentifierML2254
Location 2677270 bp
Protein summary information
Molecular mass56300.1 Da
Isoelectric point8.24
Protein length499 amino acids
Structural information
PFAMPF00982
Orthologs
M. tuberculosis H37RvRv3490
M. lepromatosis Mx1-22AMLPM_2254
Cross-references
UniProtQ50167
Gene OntologyTrehalose biosynthetic process, Transferase activity, transferring glycosyl groups
Enzyme Classification2.4.1.-
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionINVOLVED IN OSMOREGULATORY TREHALOSE BIOSYNTHESIS. Mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) [CATALYTIC ACTIVITY: UDP-GLUCOSE + D-GLUCOSE 6-PHOSPHATE = UDP + ALPHA,ALPHA-TREHALOSE 6-PHOSPHATE].
ProductPROBABLE ALPHA, ALPHA-TREHALOSE-PHOSPHATE SYNTHASE [UDP-FORMING] OTSA (TREHALOSE-6-PHOSPHATE SYNTHASE) (UDP-GLUCOSE-GLUCOSEPHOSPHATE GLUCOSYLTRANSFERASE) (TREHALOSEPHOSPHATE-UDP GLUCOSYLTRANSFERASE) (TREHALOSE-6-PHOSPHATE SYNTHETASE) (TREHALOSE-PHOSPHATE SYNTHASE) (TREHALOSE-PHOSPHATE SYNTHETASE) (TRANSGLUCOSYLASE) (TREHALOSEPHOSPHATE-UDP GLUCOSYL TRANSFERASE)
CommentsML2254, len: 498 aa. Probable otsA, trehalose-phosphate synthase (EC 2.4.1.15). Similar to Mycobacterium tuberculosis otsA or Rv3490 or MTCY13E12.43 TR:O06353 (EMBL:Z95390) (500 aa) fasta scores: E(): 0, 80.3% identity in 497 aa. Similar to Candida albicans alpha,alpha-trehalose-phosphate synthase [UDP-forming] tps1 SW:TPS1_CANAL (Q92410) (478 aa) fasta scores: E(): 0, 37.8% identity in 473 aa. Previously sequenced as TR:Q50167 (EMBL:U15187). Contains Pfam match to entry PF00982 TrehaloseP_syn, Trehalose-6-phosphate synthase domain.
Functional categoryVirulence, detoxification, adaptation
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS26772702678766+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2254|otsA
MTSRGNHGSKTSSDKHLGDSDFVVVANRLPVDQVRLPDGTAIWKRSPGGLVTALEPLLRQRRGAWVGWPGVINDNVDLDLTIKSIVQDGLTLYPVRLNTHDVAEYYEGFSNATLWPLYHDVIVKPIYHCEWWERYVDVNRRFAETTSRTAAYGGTVWVQDYQLQLVPKMLRIMRPDLTIGFFLHIPFPPVELFMQIPWRTEIIEGLLGADLVGFHLTSGAQNFLFLSRHLLGANTSRGLVGVRSRFGEVQLKSHTVQVGAFPISIDSKEIDQATRDRNVRRRAREIRAELGNPRKILLGVDRLDYTKGIDVRLRAFAELLAEGRAKRDDTVLVQLATPSRERVESYKILRNDIERQVGHINGEYGEVGHPVVHYLHRPIPRDELIAFYVASDVMLVTPLRDGMNLVAKEYVACRNDLGGALVLSEFTGAAAELRQAYLVNPHDLEGVKDTIEAALNQLAEEARRRMRSLRRQVLAHDVDRWARSFLDALAEAPARDAT
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