Gene ML2257c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemenE
Gene length1107 bp
IdentifierML2257c
Location 2681384 bp
Protein summary information
Molecular mass37607.2 Da
Isoelectric point6.09
Protein length369 amino acids
Structural information
PFAMPF00501
Orthologs
M. tuberculosis H37RvRv0542c
M. lepromatosis Mx1-22AMLPM_2257
Cross-references
UniProtQ9CBB8
Gene OntologyMetabolic process, Ligase activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)
CommentsML2257c, len: 368 aa. Possible menE, o-succinylbenzoic acid-CoA ligase (EC 6.2.1.26). Similar to Mycobacterium tuberculosis MenE or Rv0542c or MTCY25D10.21C TR:O06408 (EMBL:Z95558) fasta scores: E(): 0, 78.3% identity in 359 aa, and to Escherichia coli o-succinylbenzoic acid--coa ligase MENE SW:MENE_ECOLI (P37353; P78253; P78178) fasta scores: E(): 7e-18, 30.0% identity in 377 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS26813842682490-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2257c|menE
LLLPTLERILDGRAPAMVVVPAQHEPIAALRALRVGEEIDDDVALVATTSGTTGVPKGALLTAAALTASASATHDRLGGPGSWLLALPPYHIGGLQVLVRSVLAGSVPIELDISAGFDLAKLPDAVGRLGTGRRYTSLVATQLAKALTDSTATAVLAELDAVLVGGGPAPRPILDAATSAGIMVVGTYGMSETAGGCVYDGVPLDGVCIRVLVNGHVAIGGATLAKGYRNPIVPDPFAESGWFHTDDLGTVDGSGVLTVLGRADDAISTGGLTVLPGPVEAALCTHPAVSDCAVFGLTDDRLGQRVVAAVVLTDGYATPTLSMLRAHVTRRLDAMAAPRELHIVDTLPRRGIGKVDRTALVRRFAKSG
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