Gene ML2268
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE MUCONATE CYCLOISOMERASE MENC (CIS,CIS-MUCONATE LACTONIZING ENZYME) (MLE) |
| Comments | ML2268, len: 334 aa. Probable menC, muconate cycloisomerase (EC 5.5.1.1). Similar to Mycobacterium tuberculosis MenC or Rv0553 or MTCY25D10.32 TR:O06419 (EMBL:Z95558) (326 aa) fasta scores: E(): 0, 79.1% identity in 326 aa. Similar to isomerases e.g. Pseudomonas sp. chloromuconate cycloisomerase tcbD SW:TCBD_PSESQ (P27099) (370 aa) fasta scores: E(): 2.6e-10, 31.4% identity in 226 aa and to Rhodococcus opacus muconate cycloisomerase I catB SW:CATB_RHOOP (P95608) (373 aa) fasta scores: E(): 4.4e-09, 29.8% identity in 225 aa. Also similar to Amycolatopsis sp. N-acylamino acid racemase aaaR TR:Q44244 (EMBL:D30738) (368 aa) fasta scores: E(): 2.5e-06, 30.0% identity in 243 aa. Contains Pfam match to entry PF01188 MR_MLE, Mandelate racemase / muconate lactonizing enzyme family. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2691804 | 2692808 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2268|menC
VIPTLTELLDRLHVVALPMRVRFRGITTREVALIDGPAGWGEFGAFLEYQPLEASAWLVAGIEAAYGEPPEGRRDRIPINATVPAVSATQVPEVLARFPGVRTAKVKVAEPGQNLADDVDRVNAVRELVETVRVDANGGWSVEAAAQAAVALTADGPLEYLEQPCATVAELAALRRRVDIPIAADESIRKADDPLAVVRSHAADVAVLKVAPLGGIASFLAIAAQIDIPVVVSSALDSVVGITAGLIAAAALPELDYACGLGTGRLFVADVAEPMLPVDGFLPVGPVTPDPARLQALGTPPARRQWWIDRVKTCYSLLVPCAGDQSGLRRPRDR
Bibliography
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