Gene ML2270 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemenD
Gene length1671 bp
IdentifierML2270
Location 2693812 bp
Protein summary information
Molecular mass58350.4 Da
Isoelectric point6.51
Protein length557 amino acids
Structural information
PFAMPF02776
Orthologs
M. tuberculosis H37RvRv0555
M. lepromatosis Mx1-22AMLPM_2270
Cross-references
UniProtQ9CBB0
Gene OntologyMagnesium ion binding, Manganese ion binding, Menaquinone biosynthetic process, Thiamine pyrophosphate binding, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity
Enzyme Classification2.2.1.9
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionINVOLVED IN MENAQUINONE BIOSYNTHESIS (AT THE FIRST STEP) [CATALYTIC ACTIVITY 1: ISOCHORISMATE + 2-KETOGLUTARATE = 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE + PYRUVATE + CO(2)] [CATALYTIC ACTIVITY 2: 2-OXOGLUTARATE = SUCCINATE SEMIALDEHYDE + CO(2)].
ProductPROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SHCHC SYNTHASE) + 2-OXOGLUTARATE DECARBOXYLASE (ALPHA- KETOGLUTARATE DECARBOXYLASE) (KDC)
CommentsML2270, len: 556 aa. Probable menD, menaquinone biosynthesis protein, including 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (EC 4.1.3.-) and 2-oxoglutarate decarboxylase (EC 4.1.1.71) activities. Similar to Mycobacterium tuberculosis menD or Rv0555 or MTCY25D10.34 TR:O06421 (EMBL:Z95558) (554 aa) fasta scores: E(): 0, 85.4% identity in 556 aa. Similar to Bacillus subtilis menaquinone biosynthesis protein MenD (includes 2-succinyl-6-hydroxy- 2,4-cyclohexadiene-1-carboxylate synthase, 2-oxoglutarate decarboxylase) menD SW:MEND_BACSU (P23970; P23969; O34492) (580 aa) fasta scores: E(): 2.9e-21, 31.6% identity in 594 aa.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS26938122695482+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2270|menD
MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADHAGRIRLHVRIDERTAGYLAIGLAVAAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTMEQLGYFGTQVRAAISLGLAEDAPERLDSLNATWRSATCRVLVAATGSRTANAGPVQFDIPLREPLIPDPEPHGAITPQGRPGGKPWTYIPQVTFDQPLEIDLSADTVVIAGHGAGVHPNLTELPIVAEPTAPFGPYRPYPLHPLALPLLHPKQVIMLGRPTLHRPVSALLADPQVPVYALTTGPCWPDVSGNSQAAGTRAVTTGTPHPAWLQRCAEMNQHAISTVRSQLAAHPLITGLHVAAAVADALRPGDQLVLGASNPVRDMALVGLSTDGIQVRSNRGVAGIDGTVSTAIGAALAYERSPGYAGSTDRPARTVALIGDLAFVHDSSGLLIGPTEPTPQQLKIVVSNDNGGGIFELLEQGDPRLSAVSSRIFGTPHDVDVGALCRAYHVEGRQIEVDKLREALDEPGVGMRVLEVKADRSSLRQLHAAITATL
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