Gene ML2297 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameephE
Gene length975 bp
IdentifierML2297
Location 2722017 bp
Protein summary information
Molecular mass36211.4 Da
Isoelectric point10.45
Protein length325 amino acids
Structural information
PFAMPF00561
Orthologs
M. tuberculosis H37RvRv3670
M. lepromatosis Mx1-22AMLPM_2297
Cross-references
UniProtQ9CB96
Gene OntologyHydrolase activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE)
CommentsML2297, len: 324 aa. Possible ephE, epoxide hydrolase (EC 3.3.2.3). Similar to Mycobacterium tuberculosis putative epoxide hydrolase Rv3670|ephE or MTV025.018 TR:O69638 (EMBL:AL022121) (327 aa) fasta scores: E(): 0, 80.6% identity in 324 aa. Similarto many putative hydrolases and shows weak similarity to Homo sapiens soluble epoxide hydrolase ephX2 SW:HYES_HUMAN (P34913) (554 aa) fasta scores: E(): 3.1e-12, 28.1% id in 285 aa. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold.
Functional categoryVirulence, detoxification, adaptation
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS27220172722991+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2297|ephE
MAMSNPSVTRIAGPWHHLDVHANGIRFHVVEAVPTQPAGQDCAPSATARPLVMLLHGFGSFWWSWRHQLRGLTEARLVAVDLRGYGGSDKPPRGYDGWTLAGDTAGLIRALGHSSATLVGHAEGGLACWATALLHPRLVRAIALINSPHPAALRRSMLTHRNQGYALLPTLLRYQLPIWPERLLTRNNAAEIERLVRSRSSAKWQACEDFAVTIDHLRIAIQIPAAAHCALEYQRWAVRSQLRNEGRKFMKSMSRPFSVPLLHVRGDADPYLLADSVDRTRRYAPHGRYVSVSDAGHFSHEEAPEEINRYLTRFLKQVHGPRLS
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