Gene ML2308 (pon1)
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN PEPTIDOGLYCAN SYNTHESIS (AT THE FINAL STAGES), CELL WALL FORMATION. SYNTHESIS OF CROSS-LINKED PEPTIDOGLYCAN FROM THE LIPID INTERMEDIATES. THE ENZYME HAS A PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE N-TERMINAL DOMAIN (FORMATION OF LINEAR GLYCAN STRANDS) AND A PENICILLIN-SENSITIVE TRANSPEPTIDASE C-TERMINAL DOMAIN (CROSS-LINKING OF THE PEPTIDE SUBUNITS). SUPPOSED INVOLVED IN STATIONARY-PHASE SURVIVAL. |
| Product | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE (PEPTIDOGLYCAN TGASE) + PENICILLIN-SENSITIVE TRANSPEPTIDASE (DD-TRANSPEPTIDASE)] |
| Comments | ML2308, len: 803 aa. Probable ponA2, penicillin-binding protein (class A), bienzymatic membrane-associated protein with transglycosylase (EC 2.4.2.-) and transpeptidase (EC 3.4.-.-) activities. Previously characterised Mycobacterium leprae penicillin-binding protein Pon1 TR:P72351 (EMBL:S82044) (821 aa) fasta scores: E(): 0, 98.6% identity in 783 aa. Contains a possible N-terminal signal sequence. Contains Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain. Contains Pfam match to entry PF00912 Transglycosyl, Transglycosylase. NOte previously known as pon1. |
| Functional category | Cell wall and cell processes |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2732194 | 2734605 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2308|ponA2
MSERLPAVLAVLKLAGYCLLAGVVTTAMMFPLAGGLGVISNRASEVVANGSAQLLEGEVPAVSTMVDAKGNTIAWLYSQRRFEVPTDKIANTMKLAIVSIEDKRFTDHNGVDWPGTLTGLAGYASGDVDTRGGSTIEQQYVKNYQLLVTAQTDAEKRAAVETTPARKLREIRIALTLDKTFTKPEILTRYLNLVSFGNNSFGVQDAAQTYFGVNASDLNWQQAALLAGMVQSTSTLNPYTNPEGALARRNLVLDTMIENLPQDAEALRAAKTEPLGILPRPNELPRGCIAAGDRAFFCDYVQEYLSHAGISKDRLAKGGYLIRTTLDPNVQAPVKAAIDKFASPNLAGISSVMSVITPGKDAHRVIAMGSNRRYGLDTEAGETMRPQTFSLVGDGAGSVFKIFTTAAALDMGMGINAKLEVPSRFQAKGMGSGGAKGCPKETWCVINAGNYRGSMNVTDALATSPNTAFAKLIQQVGVARTVDMAIKLGLRSYTTPGTARDYNPDSNESLADFVKRQNIGSFTLGPIKVNALELSNVAATLASGGMWCPPNPIDKLFDRNGNEVAVTVETCDRVVPEGLANTLANAMSKDTKGSGTAAGSAGAAGWDLPMSGKTGTTEAHRSSGFVGFTNHYAAANYIYDDSTSPTNLCSGPLRHCSNGDLYGGNEPARTWFTAMKPIATKFGEVRLPPTDPRYVDGSPGSQVPSVTGLDLDAARQRLKGAGFQVADQPTLINSTAKLGAVVGTTPSGQTIPGSIITIQTSSGIPPAPPPPPEGGPPMPPSVGSQVIEIPGLPPITIPLLAPP
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