Gene ML2322c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED AT THE SECOND STEP IN THE COMMON BIOSYNTHETIC PATHWAY LEADING FROM ASP TO THE CELL WALL PRECURSOR MESO-DIAMINOPIMELATE, TO LYS, TO MET, TO ILE AND TO THR [CATALYTIC ACTIVITY: L-ASPARTATE-SEMIALDEHYDE + ORTHOPHOSPHATE + NADP(+) = L-ASPARTYL PHOSPHATE + NADPH]. |
| Product | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE ASD (ASA DEHYDROGENASE) (ASADH) (ASPARTIC SEMIALDEHYDE DEHYDROGENASE) (L-ASPARTATE-BETA-SEMIALDEHYDE DEHYDROGENASE) |
| Comments | ML2322c, len: 351 aa. asd, aspartate semialdehyde dehydrogenase (EC 1.2.1.11). Similar to Mycobacterium tuberculosis aspartate-semialdehyde dehydrogenase Rv3708c SW:DHAS_MYCTU (345 aa) fasta scores: E(): 0, 84.4% identity in 347 aa, and to Mycobacterium bovis aspartate-semialdehyde dehydrogenase SW:DHAS_MYCBO (345 aa) fasta scores: E(): 0, 82.1% identity in 347 aa. Contains Pfam match to entry PF01118 Semialdhyde_dh, Semialdehyde dehydrogenase. Contains PS01103 Aspartate-semialdehyde dehydrogenase signature. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2751631 | 2752686 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2322c|asd
MATRGLAIGVVGATGQVGHVMRTLLEQRDFRADSVRFFASARSQGRKLAFRGQKIEVEDAETADPTGLDIALFSAGASMSRVQAPRFAAAGVTVIDNSSAWRRDAQVPLVVSEVNYNRDVRDAFPLPKGIIANPNCTTMVSMPVLKVLHDEAQLLRMVVSSYQAVSGSGLAGVAELAAQVRAVIDVAEQLIHDGGVVQFPAPSKYVAPIAFNVVPLAGSLVDDDSGETDEDQKLRFESCKILGIPDLLVSGTCVRVPVFTGHSLSINAEFARPLSPQRARDLLGGAPGVKLVDVPTPLASAGVDESLVGRIRRDPGVPDGRGLALFVSGDNLRKGAALNAIQIAELLATQL
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