Gene ML2323c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED AT THE FIRST STEP IN THE COMMON BIOSYNTHETIC PATHWAY LEADING FROM ASP TO THE CELL WALL PRECURSOR MESO-DIAMINOPIMELATE, TO LYS, TO MET, TO ILE AND TO THR [CATALYTIC ACTIVITY: ATP + L-ASPARTATE = ADP + 4-PHOSPHO-L-ASPARTATE]. POSSIBLY ACTS IN TETRAMER CONFIGURATION, TETRAMER CONSISTING OF TWO ALPHA (CATALYTIC ACTIVITY) AND TWO BETA (FUNCTION NOT KNOWN) CHAINS. |
| Product | ASPARTOKINASE ASK (ASPARTATE KINASE) [CONTAINS: ASPARTOKINASE ALPHA SUBUNIT (ASK-ALPHA); AND ASPARTOKINASE BETA SUBUNIT (ASK-BETA)] |
| Comments | ML2323c, len: 421 aa. ask, aspartokinase (EC 2.7.2.4). Similar to Mycobacterium tuberculosis aspartokinase ask or Rv3709c or MTV025.057C SW:AK_MYCTU (P97048; O69676; P97181) (421 aa) fasta scores: E(): 0, 92.6% identity in 421 aa, and to Mycobacterium smegmatis aspartokinase asK SW:AK_MYCSM (P41403) (421 aa) fasta scores: E(): 0, 85.3% identity in 421 aa. Contains Pfam match to entry PF00696 aakinase, Amino acid kinase family. Contains Pfam match to entry PF01842 ACT, ACT domain. Contains PS00324 Aspartokinase signature. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2752686 | 2753951 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2323c|ask
VALVVQKYGGSSVADADRIRRVAERIVQTKKQGNDIVVVVSAMGDTTDDLLDLAQQVCPEPPARELDMLLTAGERISNALVAMAIESFGAQARSFTGSQAGVITTGTHGNAKIIDVTPTRLQFALDEGRIVLVAGFQGVSQDTRDITTLGRGGSDTTAIAMAAALGADVCEIYTDVDGIFSADPRVVHNARKLDTVTFEEMLEMAACGAKVLMLRCVEYARRHNIPVHVRSSYADKPGTVIVGSIKDVPMEDPILTGVAHDRSEAKVTIVGIPDIPGYAAKVFRAVADADVNIDMVLQNVSKVEDGKTDITFTCSRDSGPIAVAKLGSLRDEIGFTQLLYDDHIGKVSLIGAGMRSHPGVTATFCEALAAVGVNIELISTSEIRISVLCRDTELDKAVFALHEAFGLGGEDEVTVYAGTGR
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