Gene ML2353c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameppsE
Gene length4470 bp
IdentifierML2353c
Location 2794935 bp
Protein summary information
Molecular mass159728.0 Da
Isoelectric point5.12
Protein length1490 amino acids
Structural information
PFAMPF00109, PF00550, PF00668, PF00698, PF02801
Orthologs
M. tuberculosis H37RvRv2935
M. lepromatosis Mx1-22AMLPM_2353
Cross-references
UniProtQ49934
Gene OntologyBiosynthetic process, Cofactor binding, Transferase activity, Acp phosphopantetheine attachment site binding involved in fatty acid biosynthetic process
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE
CommentsML2353c, len: 1489 aa. Probable ppsE, type-I polyketide synthase. Similar to many polyketide synthases e.g. Mycobacterium tuberculosis Rv2935 TR:P96204 (EMBL:Z83857) (1488 aa) fasta scores: E(): 0, 82.0% id in 1493 aa. Also similar to ML2355, ML0139, ML0135, ML2354, ML2356, ML2357, ML1229 and ML0101 from M. leprae. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00606 Beta-ketoacyl synthases active site.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS27949352799404-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2353c|ppsE
VITPDNAIAVVGMAGKFPGANDVSAFWTNLRRGKESIVTLSEQELRDNGVSDKALADPAYVRRAPLLDGIDEFDADFFGLPPLAAQVLDPQHRLFLQCAWHALEDAGCDPAQFDGSIGVYGTSSPSGYLLHNLLSHRDPHTVLAEGLNFDQFSLFLQNDKDFLATRISHAFNLRGPSIAVQTACSSSLVALHLACLSLLSGECDMALAGGSSLCIPHRVGYWHSPGSMVSAVGHCRPFDVRADGTVFGSGVALVALKPLQAAIDASDRIHAVILGSAINNDGSMKMGYAAPNPAAQADVIAEAHAVAGIDSSTVSYVETHGTGTPLGDPIEIQGLKTAFEVSQIPRPGPCVLGSVKSNIGHLEVAAGIAGLIKTILCLKNKAIPATLHYTSPNRELRLDQTPFVVQSNYGPWKWDGVRRAGVSSFGVGGTNVHVVLEEASVEASTVAASTGPQVILLSAQTAAALGESREALATVLEKPGAPDLSDVAYTLAGRRKHNITMAAVVRDREHAVTVLRAAEHDNVFVGESGADTGRSAAASITTLGSDRVVFLFPGQGAQHVGMAKGLYDTESVFAEHFDTCSAGFREAMDDLDLHSAIFNGTAIDLERIDRSQPALFTVEYALAKLVESFGVGAGAYIGYSTGEYIAATLAGVFDLETAIKTVSLRARLMHESPPGAMVAVALGPEDITEYLAEYSAKGVELSAVNDPGNCVVAGPKDQIRAFSQRLDEVGIPVRRVRATHAFHTSSMEPMLREFSEFLSRQQLRVPNTPLLSNLTGTWMSEQQVTDPENWTRQISSTIRFADELDVVLSQSGRVLVEVGPGGSLTGSAMRHPRWSSGHRAVRLMRHPLQNVDDHDTFLRALGELWSAGIEVDWAPQRSVMPHLVSLPGYPFARQRHWVEPRYTIWAQIPGASSGSPVDSSVDSATVEGVRGGESQTEATLQRIWSQCLGVSSVDRNANFFDLGGDSLMAISISMAAANEGMTITPQDMYEHPTLASLTAAVDASFASSGLAKPPEAAAHPAVPPNIAYFLERGLCDTGRWRVPLILRLDPKIGSDDIRAVLTAVVNHHDVLRLSLVDNDGMWEQHIAATGEFTRLLTQTLPDGVAAGSAEERAVVSSILAELIASQSDLNEPLTAVQITTAHGGPHYLGLAVHQMVIDDASRQILGTDIITAFGQRLAGEEITLEPVTTGWREWSLRCAALATHPAALDTRSFWIENANKVNLWLADVSLNTDVIQPPGADDLIRMPCTLSVEQTSELDDARRRFRRSIQAIVLAALGRTIAQTVGDGVVAVELEGEGRSVLRPDVDVRRTIGWFTNYYPIPLVCVKGQGALAQLDAVHNTLKSIPHYGIGYGLLRYMYAPTGRVFSAQRTPDIHFRYVGVVPEPPSVDATVQFDSDMTIPVQEPVPGMGHAIELRTYRFGGSLHLDWWYDIRRIPQVTAEALAQSFPVTLSKLIQEGIATQKDAHDESEMAGAPQAGVLVDLSTLDAG
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