Gene ML2354c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameppsD
Gene length5469 bp
IdentifierML2354c
Location 2799411 bp
Protein summary information
Molecular mass193285.0 Da
Isoelectric point5.44
Protein length1823 amino acids
Structural information
PFAMPF00109, PF00550, PF00698, PF02801, PF08659
Orthologs
M. tuberculosis H37RvRv2934
M. lepromatosis Mx1-22AMLPM_2354
Cross-references
UniProtQ9CB70
Gene OntologyBiosynthetic process, Cofactor binding, Phosphopantetheine binding, Transferase activity, Acp phosphopantetheine attachment site binding involved in fatty acid biosynthetic process
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD
CommentsML2354c, len: 1822 aa. Probable ppsD, type-I polyketide synthase. Similar to many polyketide synthases e.g.Mycobacterium tuberculosis Rv2934 TR:P96203 (EMBL:Z83857) (1827 aa) fasta scores: E(): 0, 80.3% id in 1836 aa, and to Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa) fasta scores: E(): 0, 32.7% identity in 2136 aa. Also similar to ML2353, ML2355, ML0139, ML0135, ML2354, ML2356, ML2357, ML1229 and ML0101 from M. leprae. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00606 Beta-ketoacyl synthases active site.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS27994112804879-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2354c|ppsD
MTSLAERAAQLSPNARAALARELVRTGTAFPTDISEPVAVVGIGCRFPGNVTGPDSFWQLLVDGGDAISEVPPDRWDADAFYDPDPSASGRMTTKWGGFVPDVDAFDAEFFGITPREAVAMDPQHRMLLEVAWESLEHAGIAPDSLSGTRTAVMMGLSSWDYTIVNIERRADIDAYLSTGTPHCAAVGRISYLLGLRGPAMAVDTACSSSLVAIHLACQSLRLRESDVALAGGVQLILSPFTAIALSKWSALSPTGRCNSFDANADGFVRGEGCGVVVLKRLVDALRDQDRVLAVVRGSATNQDGRSNGMTAPNALAQRDVITTALRLADITPDSVNYVETHGTGTVLGDPIEFESLAATYGRGESSCALGSVKTNIGHLEAAAGVAGFIKTVLALQHAYIPRNVHFTQWNPAIDASTTRLFVPTESAPWPAIPGPRRGAVSSFGLSGTNAHVVIEQAPDTTVPISAAVGRQYVSALVVSGKTVTRVASAAAVLADWMSGPGAAAPLADVAYTLNQHRVRHPKLATVIARDHADAVAGLRALAAGQPRVGVVGCDQHAAGPGRVFVYSGQGSQWAGMGRQLLVDEPAFAKAVAELEPTFVAQVGFSLEHTLAYGDEVVGIERIQPVLVGIQLALTELWRSYGVTPDAVIGHSMGEVSAAVVAGALTPEQGLRVIATRSRLMARLSGQGAMALLELDADAAEALIADYPEVTLAVYASPRQSVIAGLPESVDAVISVVAEQNRLARRVDVEVASHHSIIDPILPELRNALADLVPQTPIIPIITTTHEHTQAVMDADYWAANLRNPVRFHQAIAQAVSGVGGFNRTCHSFIEISPHPVLTHAITDTVGGSGGHVVTSAMNRDLDQTLFFHAQLATVGVTESDSAKGRLVDLPPTPWQHSRFWVADRSAMSELAVAHPLLGVHVEMPGSGDHGWQADVGTDVCPWLADHKVFGQPIMPAAAFAEIAVAAASEALGVPAGTSGANIVIHQFEVEQMLSLDNHTPLTTQLTYHGNSKIRVEIYSRSPRGDFSRHATANVEHVSHNAVQPFQQAPGSSNGVTVSPADFYAVLRQTGQHHGPVFAVLTRITRLLDGSAETEITLPDEVPRHPGYRLHPVVLDAALQSVGAAIPDGEVAESAEVSYLPVSFEAIRVYRDIGRHALCRARLTNLDGGTGKLGKIVLIDDAGYVAAEVDGIYLRRIERRVVPLPLAQKIFDAEWIESPIPASRALEQITETARASWLVLTDWDPSIKSLTDEFIARWRSPMRRVYTANLHDESAMLAAFAETAGDPEHPPIGVVIFVGGAATGLDDGLVQARDSVWSISTVVRAIVSTWHGRSPRLWLIAGGGLSVQDDELGAPATAALKGLVRVLALENPDLRATLLDLDATQDQIAALTAELHNSASEFGGDDVIAWRGQHRFVERLCKATLDAGKDNPVVRPGAAYIVTGGLGGLGLVVARWLVDRGAGRVVLGSRSDPTEEQRKTLVELEARAEIVFLRGDVTSPGVAESLVAAAGRAGGQLRGIVHGAAVIEDSLVFTMTRENLERVWAPKATGALRMHQASVSCELDWWLGFSSVASLLGSPGQAAYACASAWLDALVMWRKASGLPSAVINWGPWSDVGVAQALVGSVLDTITPAEGIEAIDSLLAAGRTRTGVARLRADKALVAFPEMRSISYFTWVVEQLAAAGDLGDWVGSDTLADLDPAEAQRVVTERMCALIAAVMGYADRSTVNPAVPLTELGLDSLMAVRIRNGARADFGVEPPVTLILQGASLQDLTADVVRQLGLAGPKQALENADTVRDRVQQRAAVRRGAVMRRRPKPDVQGG
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