Gene ML2355c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC |
| Comments | ML2355c, len: 2201 aa. ppsC, type-I polyketide synthase. Similar to several polyketide synthases e.g. Mycobacterium tuberculosis Rv2933 TR:P96202 (EMBL:Z83857) (2188 aa) fasta scores: E(): 0, 82.3% identity in 2217 aa. Also similar to ML2353, ML2354, ML0139, ML0135, ML2354, ML2356, ML2357, ML1229 and ML0101 from M. leprae. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00133 Zinc carboxypeptidases. Contains PS00606 Beta-ketoacyl synthases active site. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2804876 | 2811481 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2355c|ppsC
MTASTPDRRAIITEALHKIDDLTARLEIAEKSSTEPIAVIGMGCRFPGGVNNPEQFWDLLCDGRSGIVRVPSDRWDADAYYTDDHTVPGTICSTEGGFLTGWQPDEFDAEFFSISPREASAMDPQQRLLIEVAWEALEDAGVAPHTIRGTQTSVFVGVTAYDYMLTLAGRLRPEDLDAYIPTGNSANFAAGRLAYILGVRGPAVVIDTACSSSLVAVHLACQSLRHRESDAALVGGTNLLLSPGPSIACSRWGMLSPAGQCKAFDVSADGYVRGEGAGVVVLKRLDDAVRDGNRILAIVRGSAVNQDGASSGVTVPNGPAQQELLRTALASSKLTAADIDYIEAHGTGTPLGDPIELDSLSKVFSDRQSRRGSVPLVIGSVKTNLGHLEAAAGIAGFIKAVLAVQRGFIPRHLNFHQLTTHASEAASRLNIASEGLEWPTVGRPRRAGVSSFGVSGTNAHVVLEQAPDPVAVPAPGPALRLVPAVSTLVVSGKTVQRVAATASVLADWMEGPGAAVPLTDVAHTLNHHRARHTKFGTVAAVDRGQAVAGLRALAAGQSTSGVVAPRDSVVGPGTVFVYSGRGSQWAGMGRQLMADEPAFAEAIAKLEHEFVVQAGFSLHEVIANGKELVGIEQIQLGLMGMQLALTELWRSYGVEPDAVIGHSMGEVAAAVVAGALTPTQGLRVTATRSRLMAPLSGQGTMALLELDAVATEALIADYPQVSLGIYASPRQTVIAGPTAMIDALIDKVRQQDGFATRVNIEVAPHNPAMDALQPQMRSELADLTPQQPTIPIISTTYEDFGSTPVFDVEHWATNMRNPVRFQQAITHASSGVGGDYHTFIEISAHPLLTHSISDILCSIAGTAEENAVGAGYLSIGTLQRDAHDTLEFHTNLNATHTSRPPRTPHPPEPHPVLPITPWQHTRHWISAMSAAYHRADTHPLLGVGVTDPTSGTRVWESQLGPDLLWLGDHVIDDLCVLPGAAYAEVALAAATDTFPNERVEGDQPWMIYELDLHQVLHVTEGTVLVTTLTGDQQRCRIEMRTRNGFSGWTTHATATVGPAESVQPSDREERTATPVDVVDELGPEDLYQRLCSAGQQHGPAFQGIVGLAVEESGAARAEVRLPSSARMGFRDFLLHPVMMDIALQTLGATRMATDLAGGPTARKTLVLPVRFAGVHVYGDVTRGVCAVGLLTATEGLDRLVGEVVLTDLDGQPLLVIDEVQMTVLGAGSDATELTDRLFTLEWEPTPLYKEVSRSSAQGGLLLIGDVAAGDPLLLALQSSLRARLSENGPPPVDCVSFSDEVKLQAAITRTDISWDGIVVVCPPRASDESLPDDAQLELAQTRTLQIAGVVQAVTQMGARKSPRLWIVTRGAQQLNAGESVTLAQTELRGIVRVLTFEHSELKATLLDIEADGTDSLDDLTEELLAGSNHDEVAYRDGQRYVNRLVPAPITPKGELAGETRRKVVELGGLGAVQLQIDQPGRLDALTVHQVKRGEPEGDQVEVRVVAAGLNFSDVLKAMGVYPGLDGGAPAIGGECVGYVTAIGDDVDSVEVGQRVIAFGPGTFGTYVGTIADLVVPIPDTLSDHEAATFGVAYLTAWHCLCEVGRLSPGERVLIHSATGGVGMAAVSIAKMLGARIYTTAGSDAKRQMLSELGVEYVGDSRSVDFADEILELTHGYGVDIILNSLADKAIQRGVQILAPGGRFIEIGKKDVYDDANLGLAALAKSASFSVVDLDLNLKLHPARYRQLLQHILAHVADGRLPVLPVTEFSLHNAADAFRLMASGKHTGKIVISIPYEGNIEAIASPPPVPLVSQDGGYLVVGGMGGLGFVFARWLAEQGAGLIVLNGRSSPSDDVTAAIADLTAAGHRIEVVTGDISEPGTADRLVHAVQSAGFRLAGVLHSAMVLADEIMLNMTDSAARRVFVPKVTGSWRLHQATAAFEVDWWLTFSSASSLLGTPGQGAYAAANAWVDGLVAYRRSLGLPAVGINWGPWAEVGRAQFFAGLGVSLLTAEQGLAAMQTVLAADRAQTGVFSLDARQWFQSFPAVAGSSLFANLRDTATLKSGERRGVGKIRAQLDVLDAAERPGHLASAIADEIRAVLRSSDPIDHDRPLEALGLDSLMGLELRNRLEASLGITLPVALVWAYPTTADLAAALCERMDYALPAEVQEATDTNAELSKAEMDLLSDLVEASELEAATRGES
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