Gene ML2356c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameppsB
Gene length4623 bp
IdentifierML2356c
Location 2811478 bp
Protein summary information
Molecular mass164211.0 Da
Isoelectric point5.11
Protein length1541 amino acids
Structural information
PFAMPF00109, PF00550, PF00698, PF02801, PF08659
Orthologs
M. tuberculosis H37RvRv2932
M. lepromatosis Mx1-22AMLPM_2356
Cross-references
UniProtQ7APV9
Gene OntologyBiosynthetic process, Cofactor binding, Transferase activity, Acp phosphopantetheine attachment site binding involved in fatty acid biosynthetic process
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB
CommentsML2356c, len: 1540 aa. Probable ppsB, type-I polyketide synthase. Similar to many polyketide synthases including: Mycobacterium tuberculosis phenolpthiocerol synthesis polyketide synthase Rv2932 SW:PPSB_MYCTU (Q10978; O53234) (1538 aa) fasta scores: E(): 0, 76.3% identity in 1561 aa and Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa) fasta scores: E(): 0, 42.2% identity in 879 aa. Also similar to ML2353, ML2354, ML0139, ML0135, ML2354, ML2355, ML2357, ML1229 and ML0101 from M. leprae. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00606 Beta-ketoacyl synthases active site.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS28114782816100-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2356c|ppsB
MRTAFSRISGMTTQQRAALIEEFTKLSRIAVAEPIAVVGIGCRFPGDVTGPDSFWDLLIDGRNAISRVPADRWDADAFYDPDPLTPGRMTTKWGGFVSDIAGFDAAFFGITPREAAAMDPQQRILLEVAWEALENAGIPPDSLGNSRTGVMIGVYFNEYQSMLASSLENVDAYSGTGNAHSITVGRISYLLGLRGPSVAVDTACSSSLVAVHLACQSLRLRETDLVLAGGVSITLRPETQIAISAWGLLSPHGRCAAFDAAADGFVRGEGAGVVVLKRLTDAVRDGDLVLAVVRGSAVNQDGRSNGVTAPNTAAQCDVITDALRSSDVAPESVNYVESHGTGTVLGDPIEFEALAATYGRGESACALGAVKTNLGHLEAAAGIAGFIKTVLAVQRGQIPPNLHFSQWNPAIDAASTRFFVPTENSSWPISDGQAGPRRAAVSSFGLGGTNAHVVIEQGPELTPVTECSSNTAVSTLVVTGKTASRVAAMAGMLADWVEGPGAEVALADVAHTLNHHRSRHAKFGTVVARDRIQAVAGLRALAAGKQAPGVVGQQDGTPGSGTVFVYSGRGSQWAGMGRQLLADEPAFTAAVAELEPVFVVHAGFSLHDVLANGKELVGIEQIQLGLIGMQLTLTELWRSYGVQPDLVIGHSLGEVAAAVVAGALTAAEGLRVTATRSRLMAPLSGQGGMALLELDAVETEALIVDYSQVTLAIYNSPRQTVIAGPTEQIDELIDRVRAQNRFASRVNIEVAPHNPAMDALQPQMRSELADVAPRTPTIPILSTTYADLGSCPVFDAQHWATNMRNPVHFQQAIMTAGTDHRTFIEISAHPLLTQAITDTLHGTRCISIGTLQRDADDTVTFHTNLNNVHTVHPPHTPHPAEPHVTIPSTPWQHTRHWITTPLASTTALQHLDRNRVTTHATGIGNTELDDWIYQLDWPTRPLTSEPGATWASSGSWLVVSDAGLSDELARLVVLADPASRVEYLAPSALDHDVSTLHDLHNALRGVDNVLYAPSVSTESVDPVDPESGYRLFHAVRRLAAAMVAGTSKPKLVVVTRNAQPVAVGERANPAHAVLWGFGRTLALEHPEIWGSVIDLDASMPPELAARCILDEVASQDEKDREDQVVYRACLRRAPRLQRRTASAVSSVKLSSGQDTTQLVIGATGNIGPHLIRQLAAMGATTIVAVSRNPSTRLLELDKNLAATGTNLISVAADATDPTAMTALFDRFGVDLPPLEGIYLAAFAGRPVLLSDMTDNDVVAMFRPKLDVASLLHRLSLKQPVKYFLLFSSISGLIGSRWLAHYTATSAFLDILGYARRLVGLPATVVAWGLWKSLADAQQDATQVSAESGLQPMTDDVAIGALPLVMSPDAPVHSVVAAADWPLLAAAYQTRGVLRMVDDLLPAPGEVLMQESEFRKALRTCQAERRHNMLFDHVSALVAKAMGLLPAETLDPSAGFFQLGMDSLMSVTLQRALSDSLGEFLPASVVFDYPTVYSLTDYLATILPEFLEPEAPSGRTTADAYDEFTESELLDQLSERLRGTQ
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