Gene ML2357c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA |
| Comments | ML2357c, len: 1871 aa. Probable ppsA, type-I polyketide synthase. Highly similar to many Prokaryotic and Eukaryotic polyketide synthases including: Mycobacterium tuberculosis phenolpthiocerol synthase rv2931 SW:PPSA_MYCTU (Q10977) (1876 aa) fasta scores: E(): 0, 76.1% identity in 1888 aa and to Penicillium patulum 6-methylsalicylic acid synthase SW:MSAS_PENPA (P22367) (1774 aa) fasta scores: E(): 0, 33.8% identity in 1823 aa. Also similar to ML2353, ML2354, ML0139, ML0135, ML2354, ML2355, ML2356, ML1229 and ML0101 from M. leprae. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains 2 Pfam matches to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00606 Beta-ketoacyl synthases active site. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2816101 | 2821716 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2357c|ppsA
MTASIGSEADLCHWLVNYLVTNIGCTPDEVDLNLSLTDLGMSSRDAVVLSGELTDLLGKTVSPIDFWEHPTINALAAYLIAPAPDPESESAPRRSVQGALEEPIAVIGMGCRFPGGISGPEALWQFLCDRRSSIGQVPNERWELFDDGSPEVKALLARTTRWGSFLEDIDAFDSEFFEISPSEADKMDPQQRLLLEVAWEALEHAGISSNSLRRSQTGVFAGSCLSEYGAIASTDLSQVDGWSNTGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLRTADANLAIAAGVNLLLSPAVFRGFDQVGALSPTGCCRAFDAAADGFVRGEGAGVVVLKRLTDAQRDGDRVLAIIRGSAVNQDGRSNGLMAPNPAAQVAVLRTAYANAAMPPTAIDYVETHGTGTLLGDPIEARALGAVLGRGRAEDSPLLIGAVKTNLGHLEAAAGIAGFIKTVLAVQRGQIPPNQRFESPNLHIPFAELRMKVVDKHMEWPDTGHLRRAAVSSFGFGGTNAHVVIEQGPELTPVTECSSNTAVSTLVVTGKTASRVAAMAGMLADWVEGPGAEVALADVAHTLNHHRSRHAKFGTVVARDRIQAVAGLRALAAGKQAPGVVGQQDGTPGSGTVFVYSGRGSQWAGMGRQLLADEPAFTAAVAELEPVFVVHAGFSLHDVLANGKELVGIEQIQLGLIGMQLTLTELWRSYGVQPDLVIGHSLGEVAAAVVAGALTAAEGLRVTATRSRLMAPLSGQGGMALLELDAVETEALIVDYSQVTLAIYNSPRQTVIAGPTEQIDELIDRVRAQNRFASRVNIEVAPHNPAMDALQPQMRSELADVAPRTPTIPILSTTYADLGSCPVFDAQHWATNMRNPVHFQQAIMTAGTDHRTFIEISAHPLLTQAITDTLHGTRCISIGTLQRDADDTVTFHTNLNNVHTVHPPHTPHPAEPHVTIPSTPWQHTRHWIPRKRSVNSIGLAPQVGTLLGQHTAVSGILPIHLWQARLAPQAKPYRGWHRVHGVEVVPASIVLRTILCAAAELGYSTLFEIRFEQPIFANLPRLIQVVVDNQLISLASSPATETPQHRWTRHVTAQLSSASARSAVPSDHPDQINGHLEVISDPIPDVASLLALCGVDGLPFEWSVKSWAKKTQQSTSRTVEIEFPDTLPDGAIAPLLDAAILIPALADVTETQFYVPASIKQVWLGDTATGPCGAVTLNRTACDDDGITVDVTVADGSGVPLALMRSLRYRALDLDNAQQDYSTVFVESHVDALTDARNFVHAIDWQPRTDLDCSNTPVASSGSVAVIGDARAGFGLLLKEAGYTLAAPADGVSEVRYVVYVADPHPATTAETDVDFAVRITAEISDLVRALAKREPGKPVALWIVTRGVYESVASSALRQSFLWGFGGVIAAEHPEMWGGLVDLAASALGADRDDILDQFGPTLASLLQTPTRSIVVLRDGVVLAPTLVPIRSEPVRKSLQCKSDGAYLITGGMGALGLLMADWLADRGARRLVLMGRTPLPPRRDWELDTLDAGLRQKIDAICALEMRGVTVEAVAVDVGHHDDVQALLAKRDRDGAAPIRGIIHAAGVTNDQLVTNMTDDPVRQVMWPKIAGCQVLHEAFPPGSVDFFYLTSSAAGIFGIPGQGSYAAANSYLDALARTRRQQGCHTMSIDWVAWRGLGFAANAQIVSDELQRMGSRDITPSEAFTAWEYVDAYDVAQAVVLPVPRSYGSAGSTAGDSYLVPARNWSQMEAAEVRKELESGLRTIIAAELRVAEAELDTDRPFAELGLNSLMAMAIRREAEQFIGIELSAIMLFNHPTVALLAAYLTKVVAPQHDSQGDEMAALSASAGGVLDSLFDRIESTSTEAEGLV
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