Gene ML2358c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namefadD26
Gene length1752 bp
IdentifierML2358c
Location 2821713 bp
Protein summary information
Molecular mass63212.0 Da
Isoelectric point5.64
Protein length584 amino acids
Structural information
PFAMPF00501
Orthologs
M. tuberculosis H37RvRv2930
M. lepromatosis Mx1-22AMLPM_2358
Cross-references
UniProtQ9Z5K5
Gene OntologyMetabolic process, Catalytic activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductFATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)
CommentsML2358c, len: 583 aa. Probable fadd26, fatty-acid-CoA synthase (EC 6.2.1.-). Similar to several e.g. Q10976|FD26_MYCTU|Rv2930 Mycobacterium tuberculosis fatty-acid-CoA ligase (583 aa), fasta scores: E(): 2e-189, (76.844% identity in 583 aa overlap); and Q7TXM1 Fatty-acid-CoA ligase FADD26from M. bovis (583 aa), fasta scores: E(): 1.1e-189, (77.015% identity in 583 aa overlap). Also similar to ML0132, ML1234, ML0138 and ML0100 from M. leprae. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS28217132823464-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2358c|fadD26
MVVTNFSVPALLKERADQQADTTAYTYIDYGSDPKGFVESLTWSQVYMRSCVLADELKLCGVPGDRVAILAPQGLEYIIAFLGALQAGFIAVPLSPPQYAIHDERVSAVLRDSQPIAILTTSFVVSDVAKYACEQDGWNAPSVIEIDLLDLNASLPLPKVPQPFTSPAYLQYTSGSTRTPAGVMVSHKNVIANVQQSMNGYFGDAAKTLNTTVVSWLPLFHDMGLILGVCAPMVAGRSSVLLSPMSFLRRPACWMQLLATTQACFSAAPNFAFELAVRRTSDDDMNGLDLGDVAGIISGSERVHIATVKRFTERFARFNLSPSVVRPSYGLAEATVYVAAPEPGTAPKAVRFDYEYLTASKAKARRAEGSVATELISYGSPDASAVRIVDPESMIENPAGMVGEIWVQGDHVAMGYWRKPEQTARTFNAKIVNPAPGTSEGPWLRTGDLGVMSDGELFIMGRIKDLLIVDGRNHYPDDIEATIQEITGGRVAAITVPDDLTEQLVAIIEYKEHGASAEDHMHKVHSVKREVTSAISKLHSLHVADLVLVSPGSIPITTSGKVRRSACVERYRSDGFKRLDVTV
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