Gene ML2359c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nametesA
Gene length786 bp
IdentifierML2359c
Location 2824110 bp
Protein summary information
Molecular mass28949.7 Da
Isoelectric point4.74
Protein length262 amino acids
Structural information
PFAMPF00975
Orthologs
M. tuberculosis H37RvRv2928
M. lepromatosis Mx1-22AMLPM_2359
Cross-references
UniProtQ9Z5K4
Gene OntologyHydrolase activity, acting on ester bonds, Biosynthetic process
Enzyme Classification3.1.2.-
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE THIOESTERASE TESA
CommentsML2359c, len: 261 aa. Probable tesA, thioesterase (EC 3.1.2.-). Similar to several thioesterases associated with macrolide anitbiotic production e.g. Streptomyces griseus probable cadicidin biosynthesis thioesterase SW:PABT_STRGR (P33586) (361 aa) fasta scores: E(): 4.9e-24, 34.4% identity in 221 aa. Also similar to Mycobacterium tuberculosis probable thioesterase Rv2928 SW:YT28_MYCTU (Q10974) (261 aa) fasta scores: E(): 0, 74.7% identity in 249 aa. Contains Pfam match to entry PF00975 Thioesterase, Thioesterase domain.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS28241102824895-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2359c|tesA
MLHVLRPGYAGAVNGHSNNGNDDETSTTPTLYIFPHAGGDATYYVPFSREFSADIKRIAVHYPGQRDGYGLPALTSIPALADEIFAIMKPSAPPEGAVAFFGHSMGGMLAFEVALRFQSAGYRLIALFVSACSAPGYIRYKQIKDFSDNDMLDLVVRMTGMNPDFFEDEEFRVGVLPTLRAARIIAGYNCPPETTVSCPIYTYIGDKDWIATQEDMKPWRERTTGAFAIRVFPGDHFYLNGNLSELVCDIEDKTLEWCDRA
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