Gene ML2378 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemmpL4
Gene length2880 bp
IdentifierML2378
Location 2846834 bp
Protein summary information
Molecular mass105216.0 Da
Isoelectric point7.71
Protein length960 amino acids
Structural information
PFAMPF03176
Orthologs
M. tuberculosis H37RvRv0450c
M. lepromatosis Mx1-22AMLPM_2378
Cross-references
UniProtP54881
Gene OntologyPlasma membrane, Integral to membrane
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL4
CommentsML2378, len: 959 aa. Probable mmpL4, conserved transmembrane protein. Similar to many membrane proteins including: Mycobacterium tuberculosis membrane protein MmpL4 or Rv0450c SW:MML4_MYCTU (O53735) (967 aa) fasta scores: E(): 0, 78.4% identity in 962 aa, and to Mycobacterium avium TmtpB TR:Q9XCF5 (EMBL:AF143772) (963 aa) fasta scores: E(): 0, 61.8% identity in 945 aa. Also similar to ML0259 a possible pseudogene similar to M. tuberculosis mmpL4. Contains multiple possible membrane spanning hydrophobic domains.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS28468342849713+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2378|mmpL4
VTVKCANDLDTHTKPPFVARMIHRFAVPIILVWLAIAVTVSVFIPSLEDVGQERSVSLSPKDAPSYIAMQKMGQVFNEGNSDSVIMIVLEGDKPLGDDAHRFYDGLIRKLRADKHVQSVQDFWGDPLTAPGAQSNDGKAAYVQLSLAGNQGELLAQESIDAVRKIVVQTPAPPGITAWVTGASALIADMHHSGDKSMIRITATSVIVILVTLLLVYRSFITVILLLFTVGIESAVARGVVALLGHTGLIGLSTFAVNLLTSLAIAAGTDYGIFITGRYQEARQANENKEAAFYTMYRGTFHVILGSGLTISGATFCLSFARMPYFQTLGVPCAVGMLIAVAVALTLGPAVLTVGSRFGLFEPKRLIKVRGWRRIGTVVVRWPLPILITTCAIAMVGLLALPGYRTNYKDRAYLPASIPANQGFAAADRHFPQARMKPEILMIESDHDMRNPADFLILDKLARGIFRVPGISRVQAITRPDGTAMDHTSIPFQISMQNAGQVQTMKYQKDRMNDLLRQAENMAETIASMRRMHQLMALLTENTHHILNDTVEMQKTTSKLRDEIANFDDFWRPIRSYFYWERHCFNIPICWSFRSIFDALDGVDQIDERLNSIVGDIKNMDLLMPQMLEQFPPMIESMESMRTIMLTMHSTMSGIFDQMNELSDNANTMGKAFDTAKNDDSFYLPPEVFKNTDFKRAMKSFLSSDGHAARFIILHRGDPASVAGIASINAIRTAAEEALKGTPLEDTKIYLAGTAAVFKDIDEGANWDLVIAGISSLCLIFIIMLIITRAFVAAAVIVGTVALSLGASFGLSVLLWQHILGIELHYLVLAMSVIVLLAVGSDYNLLLVSRFKQEIQAGLKTGIIRSMGGTGKVVTNAGLVFAFTMASMVVSDLRVIGQVGTTIGLGLLFDTLIVRSFMMPSIAALLGRWFWWPQQGRTRPLLTVAAPVGLPPDRSLVYSD
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