Gene ML2387 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namelpd
Gene length1404 bp
IdentifierML2387
Location 2856888 bp
Protein summary information
Molecular mass50045.1 Da
Isoelectric point5.85
Protein length468 amino acids
Structural information
PFAMPF00070, PF02852, PF07992
Orthologs
M. tuberculosis H37RvRv0462
M. lepromatosis Mx1-22AMLPM_2387
Cross-references
UniProtQ50068
Gene OntologyCell redox homeostasis, Cytoplasm, Dihydrolipoyl dehydrogenase activity, Glycolysis, Oxidation-reduction process, Flavin adenine dinucleotide binding
Enzyme Classification1.8.1.4
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductDIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE)
CommentsML2387, len: 467 aa. Probable lpd, dihydrolipoamide dehydrogenase. Highly similar to many dihydrolipoamide dehydrogenases including: Mycobacterium tuberculosis Rv0462 TR:O53747 (EMBL:AL021933) (464 aa) fasta scores: E(): 0, 83.1% identity in 467 aa and Bacillus subtilis SW:DLD2_BACSU (P54533) (474 aa) fasta scores: E(): 0, 43.2% identity in 477 aa. Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase. Contains PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS28568882858291+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2387|lpd
VTHYDVVVLGAGPGGYVAAIRAAQLGLSTAVVEPKYWGGICLNVGCIPSKVLLHNAELAHIFTKEAKTFGISGDASFDYGIAYDRSRKVSEGRVAGVHFLMKKNKITEIHGYGRFTDANTLSVELSEGVPETPLKVTFNNVIIATGSKTRLVPGTLLSTNVITYEEQILTRELPDSIVIVGAGAIGIEFGYVLKNYGVDVTIVEFLPRAMPNEDAEVSKEIEKQFKKMGIKILTGTKVESISDNGSHVLVAVSKDGQFQELKADKVLQAIGFAPNVDGYGLDKVGVALTADKAVDIDDYMQTNVSHIYAIGDVTGKLQLAHVAEAQGVVAAEAIAGAETLALSDYRMMPRATFCQPNVASFGLTEQQARDGGYDVVVAKFPFTANAKAHGMGDPSGFVKLVADAKYGELLGGHMIGHNVSELLPELTLAQKWDLTATELVRNVHTHPTLSEALQECFHGLIGHMINF
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