Gene ML2394c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemetB
Gene length1167 bp
IdentifierML2394c
Location 2863801 bp
Protein summary information
Molecular mass41291.8 Da
Isoelectric point5.73
Protein length389 amino acids
Structural information
PFAMPF01053
Orthologues
M. tuberculosisRv1079
Cross-references
UniProtP46807
Gene OntologyCytoplasm, Methionine biosynthetic process, Pyridoxal phosphate binding, Cystathionine gamma-synthase activity
Enzyme Classification2.5.1.48
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE CYSTATHIONINE GAMMA-SYNTHASE METB (CGS) (O-SUCCINYLHOMOSERINE [THIOL]-LYASE)
CommentsML2394c, len: 388 aa. Probable metB, cystathionine [gamma]-synthase (EC4.2.99.9 ). Similar to Mycobacterium tuberculosis cystathionine gamma-synthase Rv1079 SW:METB_MYCTU (O53427) (388 aa) fasta scores: E(): 0, 87.3% identity in 387 aa, and to Corynebacterium glutamicum cystathionine gamma-synthase MetB TR:Q9RQ97 (EMBL:AF126953) (386 aa) fasta scores: E(): 0, 61.2% id in 376 aa. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme. Contains PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS28638012864967-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2394c|metB
MSEDYRGHHGITGLATKAIHAGYRPDPATGAVNVPIYASSTFAQDGVGELRGGFEYARTGNPMRAALEASLATVEEGVFARAFSSGMAASDCALRVMLRPGDHVIIPDDVYGGTFRLIDKVFTQWNVDYTPVPLSDLDAVRAAITSRTRLIWVETPTNPLLSIADITSIGELGKKHSVKVLVDNTFASPALQQPLMLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDQAFGFLQNGAGAVPSPFDAYLTMRGLKTLVLRMQRHNENAITVAEFLAGHPSVSAVLYPGLPSHPGHEVAARQMRGFGGMVSLRMRAGRLAAQDLCARTKVFTLAESLGGVESLIEQPSAMTHASTTGSQLEVPDDLVRLSVGIEDVGDLLCDLKQALN
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