Gene ML2396c (cysM2) in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namecbs
Gene length1395 bp
IdentifierML2396c
Location 2865946 bp
Protein summary information
Molecular mass48562.0 Da
Isoelectric point4.63
Protein length465 amino acids
Structural information
PFAMPF00291, PF00571
Orthologs
M. tuberculosis H37RvRv1077
M. lepromatosis Mx1-22AMLPM_2396
Cross-references
UniProtQ9CB65
Gene OntologyCysteine biosynthetic process via cystathionine, Cytoplasm, Pyridoxal phosphate binding, Cystathionine beta-synthase activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450)
CommentsML2396c, len: 464 aa. Probable cbs (previously cysM2), cystathionine beta-synthase (EC 4.2.1.22). Similar to Prokaryotic and Eukaryotic cystathionine beta-synthases including: Mycobacterium tuberculosis Rv1077 TR:O53425 (EMBL:AL021897) (464 aa) fasta scores: E(): 0, 90.1% id in 464 aa and Homo sapiens SW:CBS_HUMAN (550 aa) fasta scores: E(): 0, 39.5% identity in 479 aa. Also similar to ML0839 from M. leprae. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme. BELONGS TO THE CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY. Previously known as cysM2.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS28659462867340-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2396c|cbs
MRIAQHISDLIGGTPLVRLNSVVPAGTGVVAAKVEYFNSGGSSKDRIAAKMIDAAEASGQLKPGGTIVEPTSGNTGVGLALVAQHRGYKCVFVCPDKVSEDKRNVLLAYGAEVVVCPTAVPPDDPDSYYSVSDRLVAKIDGAWKPDQYANPAGPASHYETTGPEIWADTDGRVTHFVAGIGTGGTITGVGRYLKEVSGGLVRIIGADPEGSVYSGGTGRPYLVEGVGEDFWPAAYDPMVPDQIIAVSDSDSFNMTRRLAREEAMLVGGSCGMAVVAALQVAEEAGPAALVVVLLPDGGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQPIVGDVLRRKSGALPDLVHTHPSETVRDAIGILREYAVSQIPVVGAEPPVMAGEVVGSVSERELLSAVFEGRASLADAVSEHMGPPLRLIGDGELVSVAGEALRDSDALMVVEKGKLVGVITRYDLLGFLSEGAPLR
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