Gene ML2402 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameechA8
Gene length774 bp
IdentifierML2402
Location 2872838 bp
Protein summary information
Molecular mass27516.6 Da
Isoelectric point5.39
Protein length258 amino acids
Structural information
PFAMPF00378
Orthologs
M. tuberculosis H37RvRv1070c
M. lepromatosis Mx1-22AMLPM_2402
Cross-references
UniProtO07137
Gene OntologyFatty acid metabolic process, Enoyl-coa hydratase activity
Enzyme Classification4.2.1.17
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE ENOYL-CoA HYDRATASE ECHA8 (ENOYL HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)
CommentsML2402, len: 257 aa. Probable echA8, enoyl-CoA hydratase (EC 4.2.1.17). Similar to Mycobacterium tuberculosis probable enoyl-CoA hydratase Rv1070c SW:ECH8_MYCTU (O53418) (257 aa) fasta scores: E(): 0, 86.4% identity in 257 aa, and to Rhizobium meliloti probable enoyl-CoA hydratase SW:ECHH_RHIME (Q52995) (257 aa) fasta scores: E(): 0, 67.3% identity in 257 aa. Also similar to ML1724 from M. leprae. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family. Contains PS00166 Enoyl-CoA hydratase/isomerase signature.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS28728382873611+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2402|echA8
MKYDTILVDGYQRVGIITLNRPQALNALNSQMMNEITNAAKELDIDPDVGAILITGSPKVFAAGADIKEMASLTFTDAFDADFFSAWGKLAAVRTPMIAAVAGYALGGGCELAMMCDLLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGRTIDAAEAERSGLVSRVVLADDLLPEAKAVATTISQMSRSATRMAKEAVNRSFESTLAEGLLHERRLFHSTFVTDDQSEGMAAFIEKRAPQFTHR
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