Gene ML2406
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN MENAQUINONE BIOSYNTHESIS. CONVERSION OF 1,4-DIHYDROXY-2-NAPHTHOATE (DHNA) TO DIMETHYLMENAQUINONE (DMK). ATTACHES OCTAPRENYLPYROPHOSPHATE, A MEMBRANE-BOUND 40-CARBON SIDE CHAIN TO DHNA. THE CONVERSION OF DHNA TO DMK PROCEEDS IN THREE STAGES: THE REMOVAL OF THE CARBOXYL GROUP OF DHNA AS CO2, THE ATTACHMENT OF THE ISOPRENOID SIDE CHAIN, AND A QUINOL-TO-QUINONE OXIDATION, WHICH IS THOUGHT TO BE SPONTANEOUS. |
| Product | 1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE MENA (DHNA-OCTAPRENYLTRANSFERASE) |
| Comments | ML2406, len: 294 aa. Probable menA, 1,4-dihydroxy-2-naphthoate octaprenyltransferase (EC 2.5.1.-), integral membrane protein. Similar to Mycobacterium tuberculosis probable 1,4-dihydroxy-2-naphthoate octaprenyltransferase Rv0534c SW:MENA_MYCTU (O06400) (292 aa) fasta scores: E(): 0, 80.6% identity in 288 aa, and to Escherichia coli 1,4-dihydroxy-2-naphthoate octaprenyltransferase menA SW:MENA_ECOLI (P32166) (308 aa) fasta scores: E(): 1.6e-24, 34.4% identity in 276 aa. Contains possible membrane spanning hydrophobic domains. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2877405 | 2878289 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2406|menA
MASFAQWISGARPRTLPNAVAPVVAGTGTAAWLHSAVWWKALLALVVAVALVIGVNYANDYSDGIRGTDDHRAGPMRLVGSRLAFPRSVLTAAVVGLTVSTVAGLALALLSAPWLIMVGATCIAGAWLYTGSSKPYGYKGFGEVAVFVFFGLVAVLGTEYTQALRVDWVGLVLAVSTGALSSSVLVANNLRDIHTDTQSHKFTLAVRLGDAHTRQLYQALLVATGVLTVVLMVATSWCAVGLVATPLALRAMRPVRSGRMGPDLTPVLRDTGLAMVVWAIAVAGALTLAGSVTY
Bibliography
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