Gene ML2414c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namehemL
Gene length1341 bp
IdentifierML2414c
Location 2884711 bp
Protein summary information
Molecular mass45758.0 Da
Isoelectric point5.19
Protein length447 amino acids
Structural information
PFAMPF00202
Orthologs
M. tuberculosis H37RvRv0524
M. lepromatosis Mx1-22AMLPM_2414
Cross-references
UniProtP46716
Gene OntologyGlutamate-1-semialdehyde 2,1-aminomutase activity, Porphyrin-containing compound biosynthetic process, Pyridoxal phosphate binding, Transaminase activity, Cytoplasm
Enzyme Classification5.4.3.8
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT)
CommentsML2414c, len: 446 aa. Probable hemL, glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8). Similar to Mycobacterium tuberculosis glutamate-1-semialdehyde 2,1-aminomutase HemL Rv0524 SW:GSA_MYCTU (O06390) (462 aa) fasta scores: E(): 0, 82.4% identity in 460 aa, and to Escherichia coli glutamate-1-semialdehyde 2,1-aminomutase HemL SW:GSA_ECOLI (P23893; P78277) (426 aa) fasta scores: E(): 0, 53.0% id in 419 aa. Also similar to ML1409 from M. leprae. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS28847112886051-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2414c|hemL
VGSTDQATAPAGPAVSISAKLFEDACAVIPGGVNSPVRAFSAVGGTPLFITEARGCWLTDADGRRYVDLVCSWGPMILGHAHPAVVDAVATVAASGLSFGAPTPAETQLAAEIIGRMAPVERIRLVNSGTEATMSAVRLARGFTGRTKIIKFSGCYHGHVDALLADAGSGVATLSLPSSPGVTGAAAADTIVLPYNDIEAVRQTFARLGDQIAAVITEASPGNMGVVPPAPGYNAALRAITAEHGALLIIDEVMTGFRVSRSGWYGLDPVAADLFIFGKVMSGGMPAAAFGGRAEVMERLAPLGPVYQAGTLSGNPVAMAAGLATLRAAADAVYATLDRNADRLVAMLSEALTDAGVPHQIPRAGNMFSVFFSEAPVTDFASACNSQVWRYPAFFHALLDAGVYPPCSTFEAWFVSAALDDAAFGRIVDALPGAAAAAVAARHRES
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