Gene ML2422c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namehemA
Gene length1404 bp
IdentifierML2422c
Location 2897502 bp
Protein summary information
Molecular mass49451.2 Da
Isoelectric point6.38
Protein length468 amino acids
Structural information
PFAMPF00745, PF01488, PF05201
Orthologs
M. tuberculosis H37RvRv0509
M. lepromatosis Mx1-22AMLPM_2422
Cross-references
UniProtP46724
Gene OntologyCytoplasm, Glutamyl-trna reductase activity, Oxidation-reduction process, Porphyrin-containing compound biosynthetic process, Shikimate 3-dehydrogenase (nadp+) activity, Nadp binding
Enzyme Classification1.2.1.70
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE GLUTAMYL-TRNA REDUCTASE HEMA (GLUTR)
CommentsML2422c, len: 467 aa. Probable hemA, glutamyl-tRNA reductase (EC 1.2.1.-). Similar to Mycobacterium tuberculosis glutamyl-tRNA reductase Rv0509 SW:HEM1_MYCTU (Q11139) (468 aa) fasta scores: E(): 0, 82.3% identity in 463 aa, and to Bacillus subtilis glutamyl-tRNA reductase SW:HEM1_BACSU (P16618) (455 aa) fasta scores: E(): 0, 30.3% identity in 458 aa. Contains Pfam match to entry PF00745 GlutR, Glutaminyl-tRNA reductase. Contains PS00747 Glutamyl-tRNA reductase signature.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS28975022898905-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2422c|hemA
VSILLFGVSHRSAPVSVLEQLSLDRSDQIKIVDRVLQSPLVTEAMVLSTCNRVEVYAVVEAFHAGLSVIGQVLSEYSAMSIGDLTKYAYVRYSEAAVEHLFTVASGLDSAVVGEQQVLGQVRRAYAAAEANRTVGQVLHEVAQRALSVGKRVHSETAIDAAGVSVVSVALGIAGRTLGGLAGRIAVVIGAGAMGALSSSYLTQANVGRIHVLNRSLSRARRLAGKIGESGVPADVWTLNHLDEALADADLVVSCTGAVSPVVSLADVHHALAAMRRDETTRPLVICDLGMPRDVDPAVAKLPGVWVVDVEGVQREPSARASAADVDAARRIVAAEVATYLTRQRMAEVAPTVTALRQRAADVVEAELLRLDHRLPGLESAQREEVARTVRRVVDKLLHAPTVRIKQLASAPGGDSYTEALRELFELDQTAVDAVATAGELPVMVSGFSDTTRYGTSPAQSSSKYHAE
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