Gene ML2426
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | ESSENTIAL FOR THE CYCLOPROPANATION FUNCTION. TRANSFERS A METHYLENE GROUP FROM S-ADENOSYL-L-METHIONINE TO THE CIS DOUBLE BOND OF AN UNSATURATED FATTY ACID CHAIN RESULTING IN THE REPLACEMENT OF THE DOUBLE BOND WITH A METHYLENE BRIDGE. MYCOLIC ACIDS, WHICH REPRESENT THE MAJOR CONSTITUENT OF MYCOBACTERIAL CELL WALL COMPLEX, ACT AS SUBSTRATES [CATALYTIC ACTIVITY: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid]. |
| Product | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 2 CMAA2 (CYCLOPROPANE FATTY ACID SYNTHASE) (CFA SYNTHASE) (CYCLOPROPANE MYCOLIC ACID SYNTHASE 2) (MYCOLIC ACID TRANS-CYCLOPROPANE SYNTHETASE) |
| Comments | ML2426, len: 308 aa. Probable cmaA2, cyclopropane mycolic acid synthase 2 (EC 2.1.1.79). Similar to Mycobacterium tuberculosis cyclopropane-fatty-acyl-phospholipid synthase Rv0503c SW:CFA2_MYCTU (Q11196) (302 aa) fasta scores: E(): 0, 78.9% identity in 303 aa. Also similar to ML2459 from M. leprae. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2901524 | 2902450 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2426|cmaA2
MVPSQSHPAKTPRKQLKPPIEAVQSHYDRSNEFFKLWLDPSMTYSCAYFERPDLTLEEAQRAKRDLALSKLGLEPGMTLLDIGCGWGSTMLHAIEKYDVNVIGLTLSANQLAHNKLKFAEIDHTRTDRTKDVRLQGWEQFDEPVDRIISLGAFEHFADGAGDAGFERYDSFFKMCYDVLPDDGRMLLHTIIVPDAKETKELGLTTPMSLLRFIKFILTEIFPGGRLPKISQVDHYSSNAGFTVERYHRIGSHYVPTLNAWAAALEAHKDEAIALQGRQIYDTYMHYLTGCSDLFRDRYTDVCQFTLVK
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