Gene ML2430c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameproC
Gene length885 bp
IdentifierML2430c
Location 2905498 bp
Protein summary information
Molecular mass30236.8 Da
Isoelectric point4.48
Protein length295 amino acids
Structural information
PFAMPF03807
Orthologs
M. tuberculosis H37RvRv0500
M. lepromatosis Mx1-22AMLPM_2430
Cross-references
UniProtP46725
Gene OntologyCytoplasm, Oxidation-reduction process, Proline biosynthetic process, Pyrroline-5-carboxylate reductase activity, Binding
Enzyme Classification1.5.1.2
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE PYRROLINE-5-CARBOXYLATE REDUCTASE PROC (P5CR) (P5C REDUCTASE)
CommentsML2430c, len: 294 aa. Probable proC, pyrroline-5-carboxylate reductase (EC 1.5.1.2). Similar to Mycobacterium tuberculosis pyrroline-5-carboxylate reductase Rv0500 SW:PROC_MYCTU (Q11141) (295 aa) fasta scores: E(): 0, 82.4% identity in 295 aa, and to Escherichia coli pyrroline-5-carboxylate reductase SW:PROC_ECOLI (P00373) (269 aa) fasta scores: E(): 1.2e-17, 34.0% identity in 285 aa. Contains Pfam match to entry PF01089 P5CR, Delta 1-pyrroline-5-carboxylate reductase. Contains PS00521 Delta 1-pyrroline-5-carboxylate reductase signature.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS29054982906382-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2430c|proC
MLSSMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRARYLADTYSVLVTSVTDAVENAMFVVVAVKPTDVESVMGDLVQAAAVANDSAEQVLVTVAAGVTITYLESKLPAGTPVVRAMPNAAALVGAGVTVLAKGRFVTGQQFEDVLAMFDAVGGVLTVPESQMDAVTAVSGSGPAYFFLLVEALVDAGVAVGLTRQVATELAAQTMAGSAAMLLERMDQDRHSAEVAPLGAQVDVPAAQLRATITSPGGTTAAALRELERGGLRMVVDAAVQAAKIRSEQLRITSE
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