Gene ML2440c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namesenX3
Gene length1326 bp
IdentifierML2440c
Location 2915136 bp
Protein summary information
Molecular mass47734.2 Da
Isoelectric point6.2
Protein length442 amino acids
Structural information
PFAMPF00512, PF02518
Orthologs
M. tuberculosis H37RvRv0490
M. lepromatosis Mx1-22AMLPM_2440
Cross-references
UniProtP54883
Gene OntologyIntegral to membrane, Peptidyl-histidine phosphorylation, Plasma membrane, Phosphorelay sensor kinase activity, Phosphorelay signal transduction system, Atp binding
Enzyme Classification2.7.13.3
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3
CommentsML2440c, len: 441 aa. Probable senX3, two-component system sensor histidine kinase (EC 2.7.3.-). Similar to many proposed two-component sensor histiding kinases including: Mycobacterium tuberculosis sensor-like histidine kinase SenX3 Rv0490 SW:SEX3_MYCTU (Q11155) (410 aa) fasta scores: E(): 0, 84.0% identity in 406 aa, and to Mycobacterium bovis sensor-like histidine kinase SenX3 SW:SEX3_MYCBO (O07129) (410 aa) fasta scores: E(): 0, 83.7% identity in 406 aa. Contains Pfam match to entry PF00512 signal, Histidine kinase.
Functional categoryRegulatory proteins
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS29151362916461-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2440c|senX3
VFSALLLAGVLSGLAFVVGIVAGIRLSPRLIERRQRLANEWAGITVLQMLQRIIALMPLGAAVVDTYRDVVYLNEQAKELGLVRDRQLDDQAWRAAQQALGGDDVEFDLLPGKRPAAGRSGLSVHGHARLLSEKDRRFAVVFVHDQSDYVRMEAARRDFVANVSHELKTPVGAMALLAEALLASADDAETVSRFAEKVLIEANRLGYMVAELIELSRLQGAERLPNVTDIDVDIIVSEAIARHKVAADTAAIEVRTDPPSGLRVLGDQTLLVTALANLVSNAIAYSPGGSLVSISRRRRGDNIEIAVTDRGIGIALEDQERVFERFFRGDKARSRATGGSGLGLAIVKHVAANHNGSIGVWSKPGTGSTFTLSIPAAMPLYQDNDEQSGQPRGCDMWLNRPQREEEEFKSMTPAQAMMQSEVTRGNVNDKCPDCGGRGIAG
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