Gene ML2447c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemurB
Gene length1104 bp
IdentifierML2447c
Location 2922797 bp
Protein summary information
Molecular mass38112.4 Da
Isoelectric point6.4
Protein length368 amino acids
Structural information
PFAMPF01565, PF02873
Orthologs
M. tuberculosis H37RvRv0482
M. lepromatosis Mx1-22AMLPM_2447
Cross-references
UniProtQ9CB48
Gene OntologyUdp-n-acetylmuramate dehydrogenase activity, Cell cycle, Cell division, GO:0007047, Cytoplasm, Oxidation-reduction process, Peptidoglycan biosynthetic process, Regulation of cell shape, Flavin adenine dinucleotide binding
Enzyme Classification1.1.1.158
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE MURB (UDP-N-ACETYLMURAMATE DEHYDROGENASE)
CommentsML2447c, len: 367 aa. Probable murA, UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158). Similar to Mycobacterium tuberculosis UDP-N-acetylenolpyruvoylglucosamine reductase Rv0482 SW:MURB_MYCTU (Q11148) fasta scores: E(): 0, 79.0% identity in 372 aa, and to Escherichia coli UDP-N-acetylenolpyruvoylglucosamine reductase MurB SW:MURB_ECOLI (P08373) fasta scores: E(): 3.6e-12, 35.5% identity in 352 aa. Contains Pfam match to entry PF02215 MurB, UDP-N-acetylenolpyruvoylglucosamine reductase.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS29227972923900-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2447c|murB
MKRSAVGSFFAGAHVAEAVSLAPLTTLRVGPVAQRVITCASTEQVVDVIRQLDAPAGGRGAGPLLIFAGGSNLVIADTLADLTAVRLANAGITIDGNLVRAEAGAVWDDVVVRAIEHGLGGLECLSGIPGSAGATPVQNVGAYGAEVSDTITRVRLLERSSGSVRWVSACELRFGYRTSVFKQADPSGSQPPAVVLEVEFKLDASGQSAPLHYGELVATLDATSGQRANPHAVREAVLALRVRKGMVLDAADHDTWSVGSFFTNPVVAPDVYRQLAKMVDGPVPHYPAQDGVKLAAGWLVERAGFGKGYPDGAAPCRLSTKHVLALTNRGAATAEDVVTLARTVRNGVLEVFGITLEPEPALVGCVL
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