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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionREQUIRED FOR EXTRAPULMONARY DISSEMINATION. MEDIATES ADHERENCE TO EPITHELIAL CELLS BY BINDING TO SULFATED GLYCOCONJUGATES PRESENT AT THE SURFACE OF THESE CELLS; BINDS HEPARIN, DEXTRAN SULFATE, FUCOIDAN AND CHONDROITIN SULFATE. PROMOTES HEMAGGLUTINATION OF ERYTHROCYTES OF CERTAIN HOST SPECIES. INDUCES MYCOBACTERIAL AGGREGATION.
ProductIRON-REGULATED HEPARIN BINDING HEMAGGLUTININ HBHA (ADHESIN)
CommentsML2454c, len: 188 aa. Probable hbhA, iron-regulated herapin binding hemagglutinin. Similar to Mycobacterium tuberculosis heparin-binding hemagglutinin Rv0475 TR:O85733 (EMBL:AF074390) fasta scores: E(): 0, 81.4% identity in 199 aa. Contains a possible N-terminal signal sequence.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS29281252928691-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML2454c|hbhA
MAENPNVDDLRAPLLAALGAADLALTTVNELVGNMRERAEETRIDTRSRVEESRARVAKLQEVLPEHLSELREKFTADELRKAAEGYLEAATNRYNELVERGEAALERLRSRPVFEDASARAEGYVDQAVELTQEALGTVASQTRAVGGRAAKLVGIELPKKAAAPARKAPAKKAPAKKAPAKKVTQK
      
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