Gene ML2454c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namehbhA
Gene length567 bp
IdentifierML2454c
Location 2928125 bp
Protein summary information
Molecular mass20421.2 Da
Isoelectric point9.74
Protein length189 amino acids
Orthologs
M. tuberculosis H37RvRv0475
M. lepromatosis Mx1-22AMLPM_2454
Cross-references
UniProtQ9CB42
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionREQUIRED FOR EXTRAPULMONARY DISSEMINATION. MEDIATES ADHERENCE TO EPITHELIAL CELLS BY BINDING TO SULFATED GLYCOCONJUGATES PRESENT AT THE SURFACE OF THESE CELLS; BINDS HEPARIN, DEXTRAN SULFATE, FUCOIDAN AND CHONDROITIN SULFATE. PROMOTES HEMAGGLUTINATION OF ERYTHROCYTES OF CERTAIN HOST SPECIES. INDUCES MYCOBACTERIAL AGGREGATION.
ProductIRON-REGULATED HEPARIN BINDING HEMAGGLUTININ HBHA (ADHESIN)
CommentsML2454c, len: 188 aa. Probable hbhA, iron-regulated herapin binding hemagglutinin. Similar to Mycobacterium tuberculosis heparin-binding hemagglutinin Rv0475 TR:O85733 (EMBL:AF074390) fasta scores: E(): 0, 81.4% identity in 199 aa. Contains a possible N-terminal signal sequence.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS29281252928691-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2454c|hbhA
MAENPNVDDLRAPLLAALGAADLALTTVNELVGNMRERAEETRIDTRSRVEESRARVAKLQEVLPEHLSELREKFTADELRKAAEGYLEAATNRYNELVERGEAALERLRSRPVFEDASARAEGYVDQAVELTQEALGTVASQTRAVGGRAAKLVGIELPKKAAAPARKAPAKKAPAKKAPAKKVTQK
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