Gene ML2457 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameML2457
Gene length702 bp
IdentifierML2457
Location 2930186 bp
Protein summary information
Molecular mass26097.2 Da
Isoelectric point9.81
Protein length234 amino acids
Structural information
PFAMPF00440
Orthologs
M. tuberculosis H37RvRv0472c
M. lepromatosis Mx1-22AMLPM_2457
Cross-references
UniProtQ9CB41
Gene OntologySequence-specific dna binding transcription factor activity, Regulation of transcription, dna-dependent
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY)
CommentsML2457, len: 233 aa. Probable regulatory protein, possibly tetR family. Similar to several putative trancriptional regulators e.g. Mycobacterium tuberculosis putative regulatory protein Rv0472c TR:O53757 (EMBL:AL021933) fasta scores: E(): 0, 88.8% identity in 232 aa. Contains a helix-turn-helix motif situated between residues 45..66 (+3.77 SD). Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family.
Functional categoryRegulatory proteins
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS29301862930887+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2457|ML2457
VAEHIPAVAVKTDGRKRRWHQHKVERRNELVDGTIDAIRRQGRFLSMDEIAGKIGVSKTVLYRYFIDKNDLTTAVMMRFAQTTLIPNMAAALSTNLDGFDLTREIIRVYVKTVAAEPEPYQFVMANSSASKSKVIADSERIIARMLAVMIRRRMQEAGMDAGGVEPWAYLIVGGVQLATHSWMSDPRMSADELIDYLTMLSWNALCGIVEVGGSLEKFRKQPHPSPIIPPRGP
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