Gene ML2459 (umaA2) in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepcaA
Gene length888 bp
IdentifierML2459
Location 2932070 bp
Protein summary information
Molecular mass33933.8 Da
Isoelectric point6.8
Protein length296 amino acids
Structural information
PFAMPF02353
Orthologs
M. tuberculosis H37RvRv0470c
M. lepromatosis Mx1-22AMLPM_2459
Cross-references
UniProtQ9CB40
Gene OntologyLipid biosynthetic process, Cyclopropane-fatty-acyl-phospholipid synthase activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductMYCOLIC ACID SYNTHASE PCAA (CYCLOPROPANE SYNTHASE)
CommentsML2459, len: 295 aa. Probable pcaA, Mycolic acid synthase. Highly similar to many mycobacterial mycolic acid synthases including: pcaA|Rv0470c Mycobacterium tuberculosis pcaA, Mycolic acid synthase Rv3392c SW:CFA1_MYCTU (Q11195) (287 aa), fasta scores: E(): 0, 69.0% identity in 287 aa and to Mycobacterium bovis Q7U1X4 Mycolic acid synthase PCAA (287 aa), fasta scores: E(): 5.9e-112, (81.882% identity in 287 aa overlap). Also similar to ML1900 and ML1903 from M. leprae.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS29320702932957+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2459|pcaA
MSVQLTPHFRNVQAHYDLSDDFFRLFLDPTLTYSCAYFERDDMTLEEAQLAKVDLALGKLKLEPGMTLLDIGCGWGATMKRAIEIYDVNVIGLTLSENQAAHVQKTFDELDTPRTRRVLLEGWEKFHEPVDRIVSIGAFEHFGRQRYARFFKMAHEVLPADSVMLLHTIVRPTFKDARARGMTLTHEIVHFTQFILAEIFPGGWLPTVPTVEEHATAAGFKFTRIQSLQLHYAKTLDLWAARLEANKNKAIAIQSEEVYDRYMKYLTGCAKLFRDGYTDVDQFTLEKQPATARRH
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