Gene ML2467
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | CATALYZES THE FIRST COMMITTED STEP IN THE SYNTHESIS OF DECAPRENYL DIPHOSPHATE, A MOLECULE WHICH HAS A CENTRAL ROLE IN THE BIOSYNTHESIS OF MOST FEATURES OF THE MYCOBACTERIAL CELL WALL. ADDS ONE ISOPRENE UNIT TO OMEGA,E-GERANYL DIPHOSPHATE. THE PRODUCT, OMEGA,E, Z-FARNESYL DIPHOSPHATE, IS THE PUTATIVE SUBSTRATE OF Rv2361c PRODUCT [CATALYTIC ACTIVITY: Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate]. |
| Product | SHORT (C15) CHAIN Z-ISOPRENYL DIPHOSPHATE SYNTHASE (Z-FPP SYNTHASE) (Z-FARNESYL DIPHOSPHATE SYNTHASE) (Z-FPP SYNTHETASE) (Z-FARNESYL DIPHOSPHATE SYNTHETASE) (GERANYLTRANSTRANSFERASE) (FARNESYL PYROPHOSPHATE SYNTHETASE) |
| Comments | ML2467, len: 262 aa. Possible short chain Z-isoprenyl diphosphate synthetase (EC 2.5.1.10). Similar to Mycobacterium tuberculosis short chain Z-isoprenyl diphosphate synthetase Rv1086 SW:YA86_MYCTU (O53434) fasta scores: E(): 0, 90.5% identity in 262 aa and to Synechocystis sp. undecaprenyl pyrophosphate synthetase SW:UPPS_SYNY3 (Q55482) fasta scores: E(): 5.2e-29, 40.2% identity in 239 aa. Contains Pfam match to entry PF01255 UPP_synthetase, Putative undecaprenyl diphosphate synthase. Contains PS01066 Undecaprenyl pyrophosphate synthetase family signature. |
| Functional category | Cell wall and cell processes |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2940912 | 2941700 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2467|ML2467
VEIIPPRLKEPLYALYELRLRQGLTASESRLPRHIAVLCDGNRRWARDAGYDDVSYGYRMGAAKIAEMLRWCQEAGIEMTTVYLLSTENLQRDPDELAALIEIITDVVEEICAPANRWSVRTVGDLELLGEEPACRLRGAVESTPGVAPFHVNVAVGYGGRREIVGAVRALLGKELANGATAEELVEAVTVEGIARNLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTETHWPAFRRVDFLRALRDYSMRHRRYGK
Bibliography
No article yet recorded
