Gene ML2490c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameclpB
Gene length2547 bp
IdentifierML2490c
Location 2963228 bp
Protein summary information
Molecular mass93174.7 Da
Isoelectric point4.81
Protein length849 amino acids
Structural information
PFAMPF00004, PF02861, PF07724, PF10431
Orthologs
M. tuberculosis H37RvRv0384c
M. lepromatosis Mx1-22AMLPM_2490
Cross-references
UniProtQ9CB26
Gene OntologyCytoplasm, Nucleoside-triphosphatase activity, Protein binding, Protein metabolic process, Response to stress, Atp binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE ENDOPEPTIDASE ATP BINDING PROTEIN (CHAIN B) CLPB (CLPB PROTEIN) (HEAT SHOCK PROTEIN F84.1)
CommentsML2490c, len: 848 aa. Probable clpB, endopeptidase ATP binnding protein. Similar to Mycobacterium tuberculosis ClpB protein Rv0384c SW:CLPB_MYCTU (O53719) fasta scores: E(): 0, 89.0% identity in 848 aa, and to Escherichia coli protein ClpB TR:BAA16476 (EMBL:D90887) fasta scores: E(): 0, 54.8% id in 847 aa. Also similar to ML0235 from M. leprae. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00870 Chaperonins clpA/B signature 1. Contains PS00871 Chaperonins clpA/B signature 2.
Functional categoryVirulence, detoxification, adaptation
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS29632282965774-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2490c|clpB
VDSFNPTTKMQVALTSALQAASSAGNPEIRPVHLLLAMLMQNDGIAAPLLETVGVEPDIVRNEAQRLLERLPQASGCSSQPQLSRESLAAITTAQQLATEMDDEYVSTEHLMLGLAMGDSDVAKLLTGHGASPQVLREAFVKIRGSARVTSSDPEFTYQALEKYSTDLTAQSGEGKLDPVIGRDNEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGDVPESLRDKTLVALDLGSMVAGAKYRGEFEQRLKVVLDDIKFSAGQIITFIDELHTIVGAGATGESAMDAGNMIKPMLARGELRLVGATTLDEYRRYIEKDAALERRFQQIFVGEPSVEDTVGILRGLKDRYEVHHGVRITDSALVAAAALSDRYITARFLPDKAIDLVDEAASRLRMEIDSRPVEIDEVERLVRRFEIEEMALVNEEDEASKERLETLRAELADQKERLAELTARWQNEKNAIDVVRELKEQLETLRGESERAERDGDLAKAAELRYGRIPEVEKKLEAAVPTAQAREDVMLKEEVGPDDIANVVSAWTGIPAGRLLEGETAKLLRMEDELGKRVVGQKKAVHAVSDAVRRSRAGVADPNRPTGSFLFLGPTGVGKTELAKALADFLFDDQRAMVRVDMSEYGEKHSVARLVGAPPGYIGHDQGGQLTEAVRRRPYTVVLFDEVEKAHSDVFDVLLQVLDEGRLTDGQGRTVDFRNTIPILTSNLGSGGSEEQVMAAVRSVFKPEFINRLDDVLIFDGLNPEELVRIVDIQLEQLGKRLAQRRLQLEVSLPAKRWLAQHGFDPVYGARPLRRLVQQAIGDQLAKMLLAGEVHDGDTLPVNVRPDGEALILG
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