Gene ML2495c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namegrpE
Gene length690 bp
IdentifierML2495c
Location 2970888 bp
Protein summary information
Molecular mass24215.5 Da
Isoelectric point4.34
Protein length230 amino acids
Structural information
PFAMPF01025
Orthologs
M. tuberculosis H37RvRv0351
M. lepromatosis Mx1-22AMLPM_2495
Cross-references
UniProtQ9CB23
Gene OntologyChaperone binding, Cytoplasm, Protein folding, Protein homodimerization activity, Response to stress, Adenyl-nucleotide exchange factor activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE GRPE PROTEIN (HSP-70 COFACTOR)
CommentsML2495c, len: 229 aa. Probable grpE protein (Hsp70 cofactor). Similar to Mycobacterium tuberculosis GrpE protein Rv0351 SW:GRPE_MYCTU (P32724; O08379) fasta scores: E(): 0, 68.6% identity in 229 aa, and to Streptomyces coelicolor GrpE protein SW:GRPE_STRCO (Q05562) fasta scores: E(): 3.5e-18, 36.8% identity in 212 aa. Contains Pfam match to entry PF01025 GrpE, GrpE. Contains PS01071 grpE protein signature.
Functional categoryVirulence, detoxification, adaptation
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS29708882971577-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2495c|grpE
VTEGNPHEQVTVTDKRRIDPDTGEVRSIPLGDTPGGSEPAGMTDRSANSTDTMVDKVAELTSDLQRVQADFANYRKRALRDQQTASDRAKATVISQLLGVLDDFDRAREHGDLDSGPLKSVADKLMSALTGLGLVAFGVEGEDFDPVLHEAVQHEGDGGEGSKPVIGDVLRHGYKLGDQVLRHALVGVVDTIAGDGAETVAIVAPVDSTAKTEQGELGDNVTPHKEDGD
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