Gene ML2496c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namednaK
Gene length1863 bp
IdentifierML2496c
Location 2971574 bp
Protein summary information
Molecular mass66678.4 Da
Isoelectric point4.52
Protein length621 amino acids
Structural information
PFAMPF00012
Orthologs
M. tuberculosis H37RvRv0350
M. lepromatosis Mx1-22AMLPM_2496
Cross-references
UniProtP19993
Gene OntologyProtein folding, Response to stress, Unfolded protein binding, Atp binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE CHAPERONE PROTEIN DNAK (HEAT SHOCK PROTEIN 70) (HEAT SHOCK 70 KDA PROTEIN) (HSP70)
CommentsML2496c, len: 620 aa. Probable dnaK, 70 kD heat shock protein (molecular chaperone) (EC 3.6.1.-). Similar to Mycobacterium paratuberculosis dnak protein SW:DNAK_MYCPA (Q00488) fasta scores: E(): 0, 93.4% identity in 622 aa, and to Mycobacterium tuberculosis dnak protein Rv0350 SW:DNAK_MYCTU (P32723; O06301) fasta scores: E(): 0, 92.5% identity in 624 aa. Contains Pfam match to entry PF00012 HSP70, Hsp70 protein. Contains PS01036 Heat shock hsp70 proteins family signature 3. Contains PS00329 Heat shock hsp70 proteins family signature 2. Contains PS00297 Heat shock hsp70 proteins family signature 1.
Functional categoryVirulence, detoxification, adaptation
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS29715742973436-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2496c|dnaK
MARAVGIDLGTTNSVVSVLEGGDPVVVANSEGSRTTPSTVAFARNGEVLVGQPAKNQAVTNVDRTIRSVKRHMGSDWSIEIDGKKYTAQEISARVLMKLKRDAEAYLGEDITDAVITTPAYFNDAQRQATKEAGQIAGLNVLRIVNEPTAAALAYGLDKGEREQTILVFDLGGGTFDVSLLEIGEGVVEVRATSGDNHLGGDDWDDRIVNWLVDKFKGTSGIDLTKDKMAMQRLREAAEKAKIELSSSQSTSVNLPYITVDSDKNPLFLDEQLIRAEFQRITQDLLDRTRQPFQSVVKDAGISVSEIDHVVLVGGSTRMPAVTDLVKELTGGKEPNKGVNPDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGVMTKLIERNTTIPTKRSETFTTADDNQPSVQIQVYQGEREIASHNKLLGSFELTGIPPAPRGVPQIEVTFDIDANGIVHVTAKDKGTGKENTIKIQEGSGLSKEEIDRMVKDAEAHAEEDRKRREEADVRNQAETLVYQTEKFVKEQRETENGSRVPEDTLNKVEAAVAEAKTALGGTDISAIKSAMEKLGQDSQALGQAIYEATQAASKVGGEASAPGGSNSTDDVVDAEVVDDERESK
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