Gene ML2535c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameeccC3
Gene length3990 bp
IdentifierML2535c
Location 3016454 bp
Protein summary information
Molecular mass146131.0 Da
Isoelectric point6.39
Protein length1330 amino acids
Structural information
PFAMPF01580
Orthologs
M. tuberculosis H37RvRv0284
M. lepromatosis Mx1-22AMLPM_2535
Cross-references
UniProtQ9CD30
Gene OntologyDna binding, Cell cycle, Cell division, Chromosome segregation, Integral to membrane, Nucleoside-triphosphatase activity, Atp binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductESX CONSERVED COMPONENT ECCC3. POSSIBLE MEMBRANE PROTEIN.
CommentsML2535c, len: 1329 aa. esx conserved component, possible membrane protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0284 TR:O53689 (EMBL:AL021930) fasta scores: E(): 0, 84.2% identity in 1318 aa and to Streptomyces coelicolor ATP/GTP binding protein SC3C3.20C TR:O86653 (EMBL:AL031231) fasta scores: E(): 0, 36.0% identity in 1379 aa. Also similar in regions to several cell division proteins e.g. Coxiella burnetii cell division protein, FtsK homologue, FTSK_COXBU (P39920) E(): 4.2e-07 28.3% identity in 304. And similar to ML0053 from M. leprae. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family. Contains 3 x PS00017 ATP/GTP-binding site motif A (P-loop).
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS30164543020443-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2535c|eccC3
MSRLIFEARRRLPPPSSRKGTILIEAPSELPRVIPPSLLRRAMPYMIVILIVGMIIAMVATGMRIISPQTLFFPFVMLLAATALYRGNDNKMSTEEVDAERADYLRYLSVVRDNIRNQAAEQRAAAQWSHPEPTALAGVPGSRRQWERDPHDSDFLLVRVGRRQVPLDAALRVKDTADEIDLEPVSYSALRSLLDVHRIVRDVPTGIDLSKVSRITVFIDTESSKDEARAALRAWIAQAVTWHDPALLGVALATRDLESSDWSWLKWLPHVDIPGQLDGVGSARYLSTDPDELVSLLGAALTDRPAFTGMSVDALRHLMIVIDEPDYDLNASTLVMGRAGVTVVHCSTTPPHREQYSDPDQPILRIVRGTIERWQTGGWQPYIDTADRLGAHEAAHLARQLSRWDSNPTHAGLRSAATRGASFTTLLGIPDASRLDVTTLWAPRRRDDELRIPIGVTGTGEPLMFDLKDEAEGGMGPHGLMIGMTGSGKSQTLMSILLSLLTTHSADRLIVIYADFKGEAGADSFRNFPQVVAVISNMAEKKSLAERFADTLRGEVARRETLLREAGRRVQGSAFNSVLEYENAIAAGAVDLPPIPTLFVVADEFTLMLADHPEYAELFDYVARKGRSFRIHILFASQTLDFGKIKDIDKNTSYRIGLKVANASVSRQIIGVEDAYHIESGKEHKGMGFLVPSPGAAPIKFRSTYVDGIYEPPRSTKVRVVEVTPEPKLFTAGVVEPDHPIVISSEDEDESVAPPRKLIATIGEQLARYEPRAPKLWLPPLDESIQLTAILASAEVPQRQWRWPLGEIDKPFEMRRDLLMFDANSSAGNMVIHGGPKSGKSTALQTFILSAASLHSPRDVTFYCLDYGGGQLRAIQDLLHIGSVASALEPERIRRTFGELEQLLLSRQQREVFRDKRASGSAPDDCFGDVFLVIDNLYAFGRDNTDQFNTRNPLLAKVTELVNVGLAYGIHVIITTSSWLEVPLVMRDGFGLRLELKLPDARDSNVRVVGALRRPADAVPHDQPGRGLTMAAEHFLFAAPQLDQVAVINARHAGVAAPPVRLLPANLAPDAVGALYRGPEQVVIGQREEDLAPVVVDFANNPLLMVFGDSKSGKTTLLRHIIRTIREHSSPDQVAFIVLDRRLHLVDEPLFPDNEYTANIDRIIPAMLGLANLIEARRPPVGLSAAELSRWAFAGHIHYLLIDDVDQVPDSPAMSGPYIGQRPWTNLIGLLGQAGDLGLRVIVTGRATGSGHALMTNQLLRRLNDLQATTLMLAGNPADSGKIRGQRFSRLPAGRAILLSDSNSPTYVQLVNPLAGESVPERVNDGGFL
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