Gene ML2546c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namefadD2
Gene length1647 bp
IdentifierML2546c
Location 3033668 bp
Protein summary information
Molecular mass59455.1 Da
Isoelectric point6.72
Protein length549 amino acids
Structural information
PFAMPF00501
Orthologues
M. tuberculosisRv0270
Cross-references
UniProtQ9CD27
Gene OntologyMetabolic process, Catalytic activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)
CommentsML2546c, len: 548 aa. Probable fadD2, acyl-CoA ligase (EC 6.2.1.-). Similar to Rhizobium trifolii malonyl CoA synthetase MATB TR:Q9ZIP5 (EMBL:AF117694) fasta scores: E(): 2.4e-31, 31.2% identity in 507 aa and Mycobacterium tuberculosis hypothetical 59.9 kda protein Rv0270 TR:P95227 (EMBL:Z86089) fasta scores: E(): 0, 82.3% id in 558 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS30336683035314-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2546c|fadD2
VTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAMLPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYDDEYTKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELIARSSSAPAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRRFKPATVLEDIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRALEELGPVIYNMYGSTEIAFATIAGPKDLQINSATVGPVVKGVKVKILDDSGKEVPRGQVGRIFVGNAFPFEGYTGGGGKQIIDGLLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIGVDDKEWGARLRAFVVKKQDATIDEDAIKAYVRDHLARYKVPREVIFLEELPRNPTGKVLKRELRDFEVH
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