Gene ML2573 (gabD1) in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namegabD
Gene length1374 bp
IdentifierML2573
Location 3072692 bp
Protein summary information
Molecular mass48879.2 Da
Isoelectric point4.6
Protein length458 amino acids
Structural information
PFAMPF00171
Orthologs
M. tuberculosis H37RvRv0234c
M. lepromatosis Mx1-22AMLPM_2573
Cross-references
UniProtO69497
Gene OntologySuccinate-semialdehyde dehydrogenase [nad(p)+] activity, Tricarboxylic acid cycle, Oxidation-reduction process
Enzyme Classification1.2.1.16
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD
CommentsML2573, len: 457 aa. Probable gabD, succinate-semialdehyde dehydrogenase (EC 1.2.1.16). Similar to Mycobacterium tuberculosis GabD1 OR Rv0234c TR:P96417 (EMBL:Z92669) fasta scores: E(): 0, 82.9% identity in 479 aa, and to Escherichia coli succinate-semialdehyde dehydrogenase [NADP+] GabD SW:GABD_ECOLI (P25526) fasta scores: E(): 0, 35.4% identity in 460 aa. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family. Contains PS00070 Aldehyde dehydrogenases cysteine active site.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS30726923074065+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2573|gabD
MSIATINPATGETVKTFTPTTQDEVEDAIARAYARFDNYRHTTFTQRAKWANATADLLEAEANQSAALMTLEMGKTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAVGASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCALYLADVIARGGFPEDCFQTLLISANGVEAILRDPRVAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGGKRPDRPGWFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA
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