Gene ML2613c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namezmp1
Gene length2004 bp
IdentifierML2613c
Location 3118774 bp
Protein summary information
Molecular mass75270.6 Da
Isoelectric point4.56
Protein length668 amino acids
Structural information
PFAMPF01431, PF05649
Orthologs
M. tuberculosis H37RvRv0198c
M. lepromatosis Mx1-22AMLPM_2613
Cross-references
UniProtQ7APT3
Gene OntologyMetalloendopeptidase activity, Proteolysis, Membrane
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
Productprobable zinc metalloprotease
CommentsML2613c, len: 667 aa. Probable zinc metalloprotease (EC 3.4.24.-). Similar to Mycobacterium tuberculosis zinc metalloprotease Rv0198c TR:O53649 (EMBL:AL021928) fasta scores: E(): 0, 80.8% identity in 667 aa. Also similar to many Eukaryotic metalloproteases denoted endothelin-converting enzymes e.g. Homo sapiens ECE1 SW:ECE1_HUMAN (P42892) fasta scores: E(): 0, 32.6% identity in 685 aa. Contains Pfam match to entry PF01431 Peptidase_M13, Peptidase family M13. Contains PS00142 Neutral zinc metallopeptidases.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS31187743120777-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2613c|zmp1
VNIEAIRSGIDLSYVDANTRPQDDLFGHVNGRWLYEYEIPADRSTDGAFRHLFDQTEEQVRDLITEASGTAAAGETAEADAQRIGDLYASFLDEQTVERRGTQPLLEELALIDNATDTSDLAAVLGALQRTGMGGGVEVYVDTDSKDSTRYLLHFSQSGIGLPDESYFHDDQHAEVLAAYPEHIARMFTLVYRGERYQDPRCHAKTAARIVALETKLADAHWDVVKRRDADLSYNLRTFAELQSDGVGFDWSAWVTALGNTPESVTELVVRQPDYLTAFAALWETINLEDWKCWARWRLIRARAPWLTDDLVAADFDFYGRLLTGAEQIRNRWKRGVSLVENLMGDAVGKLYVQRHFPLHAKARVDALADNLQQAYRISISELAWMTPQTRERALAKLTKFTAKVGYPKKWRDYSQLVIDRDDLYGNCQRGYAVNHDRELAKLGGPVDRDEWFMTPQTVNAYYNPGMNEIVFPAAILQPPFFDVEADDAVNYGGIGAVIGHEIGHGFDDQGAKYDGDGNLIDWWTDDDRTEFNTRTKALIEQYNVYTPRGLDDHHVNGAFTVGENIGDLGGLSIALLAYQLSLNGQSAPVIDGLTGVQRVFFGWAQMWRSKSRDAETIRRLAVDPHSPPEFRCNGVIRNVDAFYDAFDVDEDDALFLEPQLRVRIWN
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