Gene ML2624 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepckA
Gene length1830 bp
IdentifierML2624
Location 3135283 bp
Protein summary information
Molecular mass67731.5 Da
Isoelectric point4.78
Protein length610 amino acids
Structural information
PFAMPF00821
Orthologs
M. tuberculosis H37RvRv0211
M. lepromatosis Mx1-22AMLPM_2624
Cross-references
UniProtO06084
Gene OntologyCytoplasm, Gluconeogenesis, Manganese ion binding, Phosphoenolpyruvate carboxykinase (gtp) activity, Gtp binding
Enzyme Classification4.1.1.32
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE IRON-REGULATED PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP] PCKA (PHOSPHOENOLPYRUVATE CARBOXYLASE) (PEPCK)(PEP CARBOXYKINASE)
CommentsML2624, len: 609 aa. Probable pckA, iron-regulated phosphoenolpyruvate carboxykinase (EC 4.1.1.32). Similar to many Prokaryotic and Eukaryotic phosphoenolpyruvate carboxykinases including: Mycobacterium tuberculosis Rv0211 SW:PPCK_MYCTU (P96393) fasta scores: E(): 0, 86.1% identity in 605 aa, Chlorobium limicola SW:PPCK_CHLLI (Q08262) fasta scores: E(): 0, 56.1% identity in 592 aa and to Rattus norvegicus SW:PPCC_RAT (P07379) fasta scores: E(): 0, 50.3% identity in 624 aa. Contains Pfam match to entry PF00821 PEPCK, Phosphoenolpyruvate carboxykinase. Contains PS00505 Phosphoenolpyruvate carboxykinase (GTP) signature.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS31352833137112+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2624|pckA
MTSATIPGLDTAPTNHQKLLSWLEEVAELTHPAQVVFADGSDEEWQQLTERLVAAGTFKKLNDEKHPNSYLALSDPSDVARVESRTFICSEREIDAGPTNNWMDPAEMRSTMTELYRGCMRGRTMWVVPFCMGPPGAEDPKLGVEITDSEYVVASMKVMTRMGTSALEKIGDDGFFVKALHSVGAPLQPGQQDMPWPCNETKYITHFPETREIWSYGSGYGGNALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKAYYFAAAFPSACGKTNLAMLQPTIPGWRAETLGDDIAWMRFGKDGRLYAVNPEFGFFGVAPGTNWKSNPNAMRTIAAGNTVFTNVALTDDNDVWWEGLEGEPAHLIDWKGNDWYAGKTETPAAHSNSRYCTPMSQCPILAPEWDDPRGVPISVILFGARRKTTVPLVTQARNWQHGVFMGATMGSEQTAAAEGKVGTVRRDPMAMLPFMGYHVGDYFQHWIDLGKHSDESNLPKVFFVNWFRRGEGGKFLWPGFGENSRVLKWIVDRIEHKAGGQDTLIGIVPTATDLDLDGLDISSDDVAKALAVDPAEWRNELPLIEEWFEFVGDKLPSGMQDEFEALKQRLAKED
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