Gene ML2655 (fbpC, AG58C)
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | PROTEINS OF THE ANTIGEN 85 COMPLEX ARE RESPONSIBLE FOR THE HIGH AFFINITY OF MYCOBACTERIA TO FIBRONECTIN. POSSESSES A MYCOLYLTRANSFERASE ACTIVITY REQUIRED FOR THE BIOGENESIS OF TREHALOSE DIMYCOLATE (CORD FACTOR), A DOMINANT STRUCTURE NECESSARY FOR MAINTAINING CELL WALL INTEGRITY. |
| Product | SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) |
| Comments | ML2655, len: 333 aa. fbpC2, secreted antigen 85C, mycolyltransferase (EC 2.3.1.-). Previously sequenced and characterised: Mycobacterium leprae antigen 85-C precursor SW:A85C_MYCLE (Q05862) fasta scores: E(): 0, 100.0% in 333 aa. Similar to Rv0129c|P31953|A85C_MYCTU Antigen 85-C precursor (85C) from M. tuberculosis (340 aa), fasta scores: E(): 2.2e-119, (81.381% identity in 333 aa overlap). Also similar to ML0097 and ML2028 from M. leprae. Contains a possible N-terminal signal sequence. Contains Pfam match to entry PF00756 Esterase, Putative esterase. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3177822 | 3178823 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2655|fbpC2
MKFLQQMRKLFGLAAKFPARLTIAVIGTALLAGLVGVVGDTAIAVAFSKPGLPVEYLQVPSPSMGHDIKIQFQGGGQHAVYLLDGLRAQEDYNGWDINTPAFEEYYHSGLSVIMPVGGQSSFYSNWYQPSQGNGQHYTYKWETFLTQEMPSWLQANKNVLPTGNAAVGLSMSGSSALILASYYPQQFPYAASLSGFLNPSEGWWPTMIGLAMNDSGGYNANSMWGPSTDPAWKRNDPMVQIPRLVANNTRIWVYCGNGAPNELGGDNIPAKFLESLTLSTNEIFQNTYAASGGRNGVFNFPPNGTHSWPYWNQQLVAMKPDIQQILNGSNNNA
Bibliography
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