Gene ML2677 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameML2677
Gene length711 bp
IdentifierML2677
Location 3221704 bp
Protein summary information
Molecular mass26359.8 Da
Isoelectric point10.69
Protein length237 amino acids
Structural information
PFAMPF00440
Orthologs
M. tuberculosis H37RvRv0078
Cross-references
UniProtQ7APS2
Gene OntologySequence-specific dna binding transcription factor activity, Regulation of transcription, dna-dependent
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN
CommentsML2677, len: 236 aa. Probable transcriptional regulatory protein (TetR-family). Similar to several putative transcriptional regulators including: Mycobacterium tuberculosis transcriptional regulator Rv0078 TR:O53623 (EMBL:AL021428) fasta scores: E(): 0, 71.4% in 175 aa, and Streptomyces coelicolor putative transcriptional regulatory protein TR:CAB76360 (EMBL:AL158061) fasta scores: E(): 0.048, 25.4% in 201 aa. Contains a probable helix-turn-helix motif at aa 35-56 (Score 1329, SD +3.71) Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family.
Functional categoryRegulatory proteins
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS32217043222414+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2677|ML2677
MESQRRTQEERSTATRDALTLARHRLWRLRGYAEVGTPEIAKEADTTRGAVYHQFTDKAALFRDVVETVEQDAMAQIASVVASSGAKTPVDAIRAKVDAWLEGLADPQVRQLILLYAPSVLGWAAFRDVAQHYSLGMTEQQLLSEASRARQLAQPLDHVLIGKLYESAMAIRRHHRLPEASPARNQTGAAPTHREHVARPSCEALTRHIRHRSTRTRSHRGKRGELLPRAATSSLL
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