Gene ML2680c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namednaB
Gene length1815 bp
IdentifierML2680c
Location 3230323 bp
Protein summary information
Molecular mass65876.0 Da
Isoelectric point5.66
Protein length605 amino acids
Structural information
PFAMPF00772, PF03796
Orthologs
M. tuberculosis H37RvRv0058
M. lepromatosis Mx1-22AMLPM_2680
Cross-references
UniProtP46394
Gene OntologyDna binding, Dna helicase activity, Dna replication, synthesis of rna primer, Alpha dna polymerase:primase complex, Intein-mediated protein splicing, Atp binding
Enzyme Classification3.6.1.-
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase
CommentsML2680c, len: 604 aa. Probable dnaB, replicative DNA helicase(EC 3.6.1.-). Similar to Mycobacterium tuberculosis replicative DNA helicase Rv0058 SW:DNAB_MYCTU (P71715) fasta scores: E(): 0, 66.6% in 554 aa, and to Escherichia coli replicative DNA helicase SW:DNAB_ECOLI (P03005) fasta scores: E(): 5.3e-31, 29.6% in 585 aa. Note the M. leprae DnaB orthologue contains an intein (approximately between residues 274..418). Contains a probable helix-turn-helix motif at aa 505-526 (Score 1068, SD +2.82) Contains Pfam match to entry PF00772 DnaB, DnaB-like helicase. Belongs to the helicase family. DnaB subfamily.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS32303233232137-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2680c|dnaB
MAVVDDLAHSGMDAVPPSEDFGRQPPQDLAAEQSVLGGMLLSKDAIADVLERLRSGDFYRPAHQNVYDAILDLYGRGEPADAVTVAAELDRRGLLRRIGGAPYLHTLISTVPTAANAGYYAGIVAEKALLRRLVEAGTRVVQYGYAGAEGADVAEVVDRAQAEIYDVAECRLSENYVPLEDLLQPTMDDLDAIASNGGISRGAPTGFTELDEVTNGLHPGQMIIVAARPGVGKALALDTPLPTPTGWTAMGDVAVGDELLAVDEAPTRVVAATEVMLGRPCYEIEFSDGTVIVADAQHQWPTSYGIRTSAQLRCGLDIIAAAGSTPRHAGRLTTAAFMAPVLCIDSVRRVRSVPVRCVEVDNAAHLYLAGRGMVPTHNSTLGLDFMRSCSIKHRLASVIFSLEMSKSEIVMRLLSAEAKIKLADMRSGRMTDDDWTRLARRMSEISEAPLYIDDSPNLTMMEIRAKARRLRQKTNLKLVVVDYLQLMTSGKRFESRQVEVSEFSRHLKLLAKELELPVVAISQLNRSPEQRTDKKPMLSDLRESGSLEQDADVVILLHRPDAFDRDDPRGGEADLILAKHRNGPTKTVTVAHQLHLSRFTNMAR
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