Gene ML2688c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN PEPTIDOGLYCAN SYNTHESIS (AT THE FINAL STAGES), CELL WALL FORMATION. SYNTHESIS OF CROSS-LINKED PEPTIDOGLYCAN FROM THE LIPID INTERMEDIATES. THE ENZYME HAS A PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE N-TERMINAL DOMAIN (FORMATION OF LINEAR GLYCAN STRANDS) AND A PENICILLIN-SENSITIVE TRANSPEPTIDASE C-TERMINAL DOMAIN (CROSS-LINKING OF THE PEPTIDE SUBUNITS). |
| Product | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE (PEPTIDOGLYCAN TGASE) + PENICILLIN-SENSITIVE TRANSPEPTIDASE (DD-TRANSPEPTIDASE) |
| Comments | ML2688c, len: 708 aa. Probable ponA1, bifunctional penicillin-binding protein 1a/1b (EC 2.4.2.-; 3.4.-.-). Similar to Mycobacterium tuberculosis probable penicillin-binding proteins 1a/1b TR:P71707 (EMBL:Z80775) fasta scores: E(): 0, 82.6% in 679 aa, and to Bacillus subtilis penicillin-binding proteins 1a/1b SW:PBPA_BACSU (P39793) fasta scores: E(): 3.6e-28, 27.0% in 688 aa. Contains Pfam match to entry PF00912 Transglycosyl, Transglycosylase. Contains Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain. |
| Functional category | Cell wall and cell processes |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3236668 | 3238794 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2688c|ponA1
VPGSRLNRTWLLHLNRQVNWRWVRYSLYLAVVVLLLLPIVTFTMTYFMVKVPRPGDIRTNQVSTILANNGLEIAKIVPPEGNRVDVNLSQVPVHVRQAVIAAEDRNFYSNPGFDFRASVRAVQNNLFGSGDLQGGSTITQQYVKNALVGSAQHGFDGLMRKTKELVIAIKMSDAWSKDDVLQSYLNIIYFGRGAYGISAAAKAYFDKPVEQLTCSEGALLAALIRRPSVLDPAINLKGVTARWNWVLDGMVDINALSPNDRSVQLFPATVPPDQARAQNQTTGPNGLIERQVVKELFELFNIDRQTLNTQGLQVITTIDPQAQRIVEKAVSKYLDGQDPDMRAAIVSIDPHNGAIRAYYGGADANGFDFAQAGLQTGSSFKVFALIAALEQGIGLGYRVDSSPLTVDGIKITNNGDESCGNCNIAEALKLSLNTSYYRLMLKLKNGPQAVADAAHQAGIVSSFPGVAHTLSEDGKGGPPNNGIVLGQYETRVIDMASAYATLAASGVYHRPHLVQKVVNAEGRVLFDASTADNSGDQRIAKAVADNVTAAMQPIAGYSRGHNLAGGRPSAAKTGTVQLGDTTANKDAWMVGYTPSLSTAVWVGTVKDNVPLITASGEAIYGSGLPSDIWKSTMDGALEGTPNEGFPKPTEVGGYAGVPTLAPPPPLKKVIQPTIEVAPGIIIPVGPPTTVTVPPTQALPDLTTSTTPP
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