Gene ML2692 (tbINO, ino2) in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameML2692
Gene length1110 bp
IdentifierML2692
Location 3241430 bp
Protein summary information
Molecular mass40277.6 Da
Isoelectric point5.13
Protein length370 amino acids
Structural information
PFAMPF01658, PF07994
Orthologs
M. tuberculosis H37RvRv0046c
M. lepromatosis Mx1-22AMLPM_2692
Cross-references
UniProtQ57240
Gene OntologyInositol biosynthetic process, Inositol-3-phosphate synthase activity, Phospholipid biosynthetic process, Binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable myo-inositol-1-phosphate synthase Ino1 (Inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (Glucose 6-phosphate cyclase) (Glucocycloaldolase)
CommentsML2692, len: 369 aa. Probable ino1 (alternate gene name: tbINO), myo-inositol-1-phosphate synthase (EC 5.5.1.4) (see citations below). Identical to ML0396c a possible paralogue of M. tuberculosis ino1. Equivalent to Rv0046c|P71703|AL123456 ino1, myo-inositol-1-phosphate synthase from M. tuberculosis (367 aa), Fasta scores: E(): 0, (91.8% identity in 366 aa overlap). Highly similar to other bacterial myo-inositol-1-phosphate synthase and hypothetical proteins e.g. Q8NLE6 Myo-inositol-1-phosphate synthase from Corynebacterium glutamicum (363 aa), Fasta scores: E(): 0, (73.9% identity in 361 aa overlap); and Q9X8T5|SCH24_21c Hypothetical protein from Streptomyces coelicolor (360 aa). Contains Pfam match to entry PF01658 Inos-1-P_synth, Myo-inositol-1-phosphate synthase.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS32414303242539+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2692|ML2692
MSEHNPAGAPGASTEVRVAIVGVGNCASSLVQGIEYYQNADDTSTVPGLMHVRFGPYHVRDVKFVAAFDVDAKKVGVDLSDAIFTSENNTIKIADVPPTNVVVQRGPTLDGIGKYYTDTIELSDVPPVDVVQALTEAKTDVLVSYLPVGSEEADKFYAQCAINARVAFVNALPVFIASDPVWAKKFADARVPIVGDDIKSQVGATITHRVMAKLFEDRGVQLDRTMQLNVGGNMDFLNMLERERVQSKKISKTQAVTSNVHREFNTKDIHIGPSDHVGWLDDRKWAYVRLEGRGFGDVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPVIPASSYLMKSPPQQLPDEIARAQLEEFIIDTK
Bibliography
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