Gene ML2703 (trxB)
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | THIOREDOXIN PARTICIPATES IN VARIOUS REDOX REACTIONS THROUGH THE REVERSIBLE OXIDATION OF ITS ACTIVE CENTER DITHIOL, TO A DISULFIDE, & CATALYZES DITHIOL-DISULFIDE EXCHANGE REACTIONS. FORMS TOGETHER WITH THIOREDOXIN REDUCTASE AND NADPH A REDOX ACTIVE SYSTEM WHICH DONATES ELECTRONS TO A WIDE VARIETY OF DIFFERENT METABOLIC PROCESS. SEEMS REGULATED BY SIGH (Rv3223c PRODUCT). |
| Product | THIOREDOXIN TRXC (TRX) (MPT46) |
| Comments | ML2703, len: 458 aa. Probable trxC, Thioredoxin Previously sequenced and characterised: Mycobacterium leprae bifunctional thioredoxin reductase/thioredoxin [includes: thioredoxin reductase SW:TRXB_MYCLE (P46843) fasta scores: E(): 0, 100.0% in 458 aa. Contains Pfam match to entry PF00085 thiored, Thioredoxin. Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase. Contains PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. Contains PS00194 Thioredoxin family active site. Note previously known as trxB. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3258259 | 3259635 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2703|trxC
MNTTPSAHETIHEVIVIGSGPAGYTAALYAARAQLTPLVFEGTSFGGALMTTTEVENYPGFRNGITGPELMDDMREQALRFGAELRTEDVESVSLRGPIKSVVTAEGQTYQARAVILAMGTSVRYLQIPGEQELLGRGVSACATCDGSFFRGQDIAVIGGGDSAMEEALFLTRFARSVTLVHRRDEFRASKIMLGRARNNDKIKFITNHTVVAVNGYTTVTGLRLRNTTTGEETTLVVTGVFVAIGHEPRSSLVSDVVDIDPDGYVLVKGRTTSTSMDGVFAAGDLVDRTYRQAITAAGSGCAAAIDAERWLAEHAGSKANETTEETGDVDSTDTTDWSTAMTDAKNAGVTIEVTDASFFADVLSSNKPVLVDFWATWCGPCKMVAPVLEEIASEQRNQLTVAKLDVDTNPEMAREFQVVSIPTMILFQGGQPVKRIVGAKGKAALLRDLSDVVPNLN
Bibliography
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